Prenatal genetic testing by amniocentesis appears to result in a lower risk of fetal loss than chorionic villus sampling in singleton pregnancies achieved by intracytoplasmic sperm injection

Objective: To compare pregnancy outcome after prenatal genetic testing by chorionic villus sampling (CVS) or amniocentesis in singleton pregnancies achieved by intracytoplasmic sperm injection (ICSI). Design: Retrospective analysis. Setting: Tertiary referral center. Patient(s): Eight hundred twenty-eight patients with singleton gestations achieved by ICSI. Intervention(s): Midtrimester amniocentesis (685 patients) and first-trimester CVS (143 patients). Main Outcome Measure(s): Fetal loss rate, preterm delivery rate, and proportion of babies born with low or very low birth weight. Result(s): A significant difference was observed in fetal loss rate between CVS and amniocentesis (3.7% vs. 0.9%, respectively). On the other hand, a similar preterm delivery rate was present between the two methods (11.2% vs. 12.4%, respectively). No significant difference was observed between amniocentesis and CVS in the proportion of babies with birth weight of either <1,500 g (1.8% vs. 3.8%, respectively) or between 1,500 and 2,500 (8.2% vs. 4.6%, respectively). Conclusion(s): Amniocentesis appears to result in a lower risk of fetal loss as compared with CVS in patients with a singleton pregnancy achieved by ICSI. (C) 2003 by American Society for Reproductive Medicine.