Stereospecific peptide folds. A rationally designed molecular bracelet

被引：26

作者：

Rana, S

Kundu, B

Durani, S ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

[2] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 21期

关键词：

D O I：

10.1039/b410532j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A canonical planar beta-hairpin peptide, stereochemically reengineered into a semicircular bracelet type motif by L-to-D stereochemical inversion in two pairs of its cross-strand neighbor residues, displays protein like ordering including two-state behavior in H2O, which is unusual for a small peptide of this size.

引用

收藏

页码：2462 / 2463

页数：2

相关论文

共 24 条

[1] Electrostatic interactions across a beta-sheet [J].

Blasie, CA ;

Berg, JM .

BIOCHEMISTRY, 1997, 36 (20) :6218-6222

[2] Folding free energy surface of a three-stranded β-sheet protein [J].

Bursulaya, BD ;

Brooks, CL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (43) :9947-9951

[3] Stabilization of β-hairpin peptides by salt bridges:: Role of preorganization in the energetic contribution of weak interactions [J].

Ciani, B ;

Jourdan, M ;

Searle, MS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (30) :9038-9047

[4] Interplay between hydrophobic cluster and loop propensity in β-hairpin formation:: A mechanistic study [J].

Colombo, G ;

De Mori, GMS ;

Roccatano, D .

PROTEIN SCIENCE, 2003, 12 (03) :538-550

[5]

Creighton T.E., 1997, PROTEINS STRUCTURES, VSecond

[6] The β-peptide hairpin in solution:: Conformational study of a β-hexapeptide in methanol by NMR spectroscopy and MD simulation [J].

Daura, X ;

Gademann, K ;

Schäfer, H ;

Jaun, B ;

Seebach, D ;

van Gunsteren, WF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (10) :2393-2404

[7] ASSIGNMENT OF COMPLEX H-1-NMR SPECTRA VIA TWO-DIMENSIONAL HOMONUCLEAR HARTMANN-HAHN SPECTROSCOPY [J].

DAVIS, DG ;

BAX, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (09) :2820-2821

[8]

Fasman G. D., 1996, CIRCULAR DICHROISM C

[9] Torsion angle dynamics for NMR structure calculation with the new program DYANA [J].

Guntert, P ;

Mumenthaler, C ;

Wuthrich, K .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (01) :283-298

[10] Clustering of fluorine-substituted alcohols as a factor responsible for their marked effects on proteins and peptides [J].

Hong, DP ;

Hoshino, M ;

Kuboi, R ;

Goto, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (37) :8427-8433