Outcomes of Pituitary Radiation for Cushing's Disease

被引：19

作者：

Ironside, Natasha ^{[1
]}

Chen, Ching-Jen ^{[2
]}

Lee, Cheng-Chia ^{[3
]}

Trifiletti, Daniel M. ^{[4
]}

Vance, Mary Lee ^{[5
]}

Sheehan, Jason P. ^{[2
]}

机构：

[1] Auckland City Hosp, Dept Neurosurg, Auckland Mail Ctr, Private Bag 92 024, Auckland 1142, New Zealand

[2] Univ Virginia Hlth Syst, Dept Neurol Surg, POB 800-212, Charlottesville, VA 22908 USA

[3] Taipei Vet Gen Hosp, Dept Neurosurg, 17 Floor,201,Sec 2,Shipai Rd, Taipei 11217, Taiwan

[4] Mayo Clin, Dept Radiat Oncol, 4500 San Pablo Rd South, Jacksonville, FL 32224 USA

[5] Univ Virginia Hlth Syst, Div Endocrinol & Metab, 2 Floor,Suite 2100,415 Ray C Hunt Dr, Charlottesville, VA 22908 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2018年 / 47卷 / 02期

关键词：

Cushing's disease; Stereotactic radiosurgery; Radiation therapy; Endocrine; Remission; GAMMA-KNIFE RADIOSURGERY; TERM-FOLLOW-UP; LINEAR-ACCELERATOR RADIOSURGERY; FRACTIONATED STEREOTACTIC RADIOTHERAPY; UNSUCCESSFUL TRANSSPHENOIDAL SURGERY; NELSONS SYNDROME; SINGLE-CENTER; ADENOMAS; THERAPY; MANAGEMENT;

D O I：

10.1016/j.ecl.2018.01.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Achievement of biochemical remission with preservation of normal pituitary function is the goal of treatment for Cushing's disease. For patients with persistent or recurrent Cushing's disease after transsphenoidal resection, radiation therapy may be a safe and effective treatment. Stereotactic radiosurgery is favored over conventional fractionated external beam radiation. Hormonal recurrence rates range from 0% to 36% at 8 years after treatment. Tumor control rates are high. New pituitary hormone deficiency is the most common adverse effect after stereotactic radiosurgery and external beam radiation. The effects of radiation planning optimization and use of adjuvant medication on endocrine remission rates warrant investigation.

引用

页码：349 / +

页数：18

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