Bottromycins-biosynthesis, synthesis and activity

被引：42

作者：

Franz, Laura ^{[1
]}

Kazmaier, Uli ^{[2
]}

Truman, Andrew W. ^{[3
]}

Koehnke, Jesko ^{[1
,4
]}

机构：

[1] Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Saarland Univ Campus, D-66123 Saarbrucken, Germany

[2] Saarland Univ, Organ Chem, Campus Geb C4 2, D-66123 Saarbrucken, Germany

[3] John Innes Ctr, Dept Mol Microbiol, Norwich, Norfolk, England

[4] Univ Glasgow, Sch Chem, Glasgow, Lanark, Scotland

来源：

NATURAL PRODUCT REPORTS | 2021年 / 38卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/d0np00097c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Covering: 1950s up to the end of 2020 Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.

引用

收藏

页码：1659 / 1683

页数：25

相关论文

共 136 条

[31] Chiral separation of β-methyl-amino acids by ligand exchange using capillary electrophoresis and HPLC [J].

Grobuschek, N ;

Schmid, MG ;

Tuscher, C ;

Ivanova, M ;

Gübitz, G .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2002, 27 (3-4) :599-605

[32] PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin [J].

Gust, B ;

Challis, GL ;

Fowler, K ;

Kieser, T ;

Chater, KF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1541-1546

[33]

Hata F., 1972, Patent No. [JP47010036B, 47010036]

[34] SYNTHESIS OF HOMOCHIRAL 3-SUBSTITUTED GLUTAMIC ACIDS AND PROLINES FROM PYROGLUTAMIC ACID [J].

HERDEIS, C ;

HUBMANN, HP ;

LOTTER, H .

TETRAHEDRON-ASYMMETRY, 1994, 5 (03) :351-354

[35] Secondary metabolites overproduction through transcriptional gene cluster refactoring [J].

Horbal, Liliya ;

Marques, Filipe ;

Nadmid, Suvd ;

Mendes, Marta V. ;

Luzhetskyy, Andriy .

METABOLIC ENGINEERING, 2018, 49 :299-315

[36] Structure and Biosynthesis of the Antibiotic Bottromycin D [J].

Hou, Yanpeng ;

Tianero, Ma. Diarey B. ;

Kwan, Jason C. ;

Wyche, Thomas P. ;

Michel, Cole R. ;

Ellis, Gregory A. ;

Vazquez-Rivera, Emmanuel ;

Braun, Doug R. ;

Rose, Warren E. ;

Schmidt, Eric W. ;

Bugni, Tim S. .

ORGANIC LETTERS, 2012, 14 (19) :5050-5053

[37] SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp II.: Structure determination [J].

Houge-Frydrych, CSV ;

Gilpin, ML ;

Skett, PW ;

Tyler, JW .

JOURNAL OF ANTIBIOTICS, 2000, 53 (04) :364-372

[38] Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase β subunit) of Streptomyces lividans [J].

Hu, HF ;

Zhang, Q ;

Ochi, K .

JOURNAL OF BACTERIOLOGY, 2002, 184 (14) :3984-3991

[39] Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations [J].

Hu, HF ;

Ochi, K .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (04) :1885-1892

[40] RiPP antibiotics: biosynthesis and engineering potential [J].

Hudson, Graham A. ;

Mitchell, Douglas A. .

CURRENT OPINION IN MICROBIOLOGY, 2018, 45 :61-69

← 1 2 3 4 5 6 7 8 9 10 →