Bottromycins-biosynthesis, synthesis and activity

被引：42
作者：
Franz, Laura [1 ]
Kazmaier, Uli [2 ]
Truman, Andrew W. [3 ]
Koehnke, Jesko [1 ,4 ]
机构：
[1] Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Saarland Univ Campus, D-66123 Saarbrucken, Germany
[2] Saarland Univ, Organ Chem, Campus Geb C4 2, D-66123 Saarbrucken, Germany
[3] John Innes Ctr, Dept Mol Microbiol, Norwich, Norfolk, England
[4] Univ Glasgow, Sch Chem, Glasgow, Lanark, Scotland
来源：
NATURAL PRODUCT REPORTS | 2021年 / 38卷 / 09期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1039/d0np00097c
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Covering: 1950s up to the end of 2020 Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.
引用
收藏
页码：1659 / 1683
页数：25
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