Bottromycins-biosynthesis, synthesis and activity

被引：42

作者：

Franz, Laura ^{[1
]}

Kazmaier, Uli ^{[2
]}

Truman, Andrew W. ^{[3
]}

Koehnke, Jesko ^{[1
,4
]}

机构：

[1] Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Saarland Univ Campus, D-66123 Saarbrucken, Germany

[2] Saarland Univ, Organ Chem, Campus Geb C4 2, D-66123 Saarbrucken, Germany

[3] John Innes Ctr, Dept Mol Microbiol, Norwich, Norfolk, England

[4] Univ Glasgow, Sch Chem, Glasgow, Lanark, Scotland

来源：

NATURAL PRODUCT REPORTS | 2021年 / 38卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/d0np00097c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Covering: 1950s up to the end of 2020 Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.

引用

页码：1659 / 1683

页数：25

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