The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome

被引：161

作者：

Deveson, Ira W. ^{[1
,2
]}

Hardwick, Simon A. ^{[1
,2
,3
]}

Mercer, Tim R. ^{[1
,2
,3
]}

Mattick, John S. ^{[1
,2
,3
]}

机构：

[1] Garvan Inst Med Res, Genom & Epigenet Div, Sydney, NSW, Australia

[2] Univ New South Wales, Fac Sci, Sch Biotechnol & Biomol, Sydney, NSW, Australia

[3] Univ New South Wales, St Vincents Clin Sch, Sydney, NSW, Australia

来源：

TRENDS IN GENETICS | 2017年 / 33卷 / 07期

关键词：

X-CHROMOSOME INACTIVATION; CELL RNA-SEQ; SINGLE-CELL; GENE-EXPRESSION; MESSENGER-RNA; XIST RNA; HUMAN GENOME; EVOLUTIONARY DYNAMICS; FUNCTIONAL ELEMENTS; SEQUENCING REVEALS;

D O I：

10.1016/j.tig.2017.04.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The combination of pervasive transcription and prolific alternative splicing produces a mammalian transcriptome of great breadth and diversity. The majority of transcribed genomic bases are intronic, antisense, or intergenic to protein-coding genes, yielding a plethora of short and long non-protein-coding regulatory RNAs. Long noncoding RNAs (lncRNAs) share most aspects of their biogenesis, processing, and regulation with mRNAs. However, lncRNAs are typically expressed in more restricted patterns, frequently from enhancers, and exhibit almost universal alternative splicing. These features are consistent with their role as modular epigenetic regulators. We describe here the key studies and technological advances that have shaped our understanding of the dimensions, dynamics, and biological relevance of the mammalian noncoding transcriptome.

引用

页码：464 / 478

页数：15

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