Follicular Helper T Cells in Systemic Lupus Erythematosus

被引：83

作者：

Kim, Sun Jung ^{[1
]}

Lee, Kyungwoo ^{[1
]}

Diamond, Betty ^{[1
]}

机构：

[1] Northwell Hlth, Feinstein Inst Med Res, New York, NY 10075 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

关键词：

follicular helper T cells; autoimmunity; transcription factors; human immunology; lupus models; GERMINAL CENTER B; PLASMA-CELLS; ANTIBODY-RESPONSES; DENDRITIC CELLS; CD40; LIGAND; MEMORY B; PHOSPHOINOSITIDE; 3-KINASE; AUTOANTIBODY PRODUCTION; RHEUMATOID-ARTHRITIS; INCREASED FREQUENCY;

D O I：

10.3389/fimmu.2018.01793

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4+ follicular helper T (Tfh) cells constitute a subset of effector T cells that participate in the generation of high-affinity humoral responses. They express the chemokine receptor CXCR5 and produce the cytokine IL-21, both of which are required for their contribution to germinal center formation. Uncontrolled expansion of Tfh cells is observed in various mouse models of systemic autoimmune diseases and in patients with these diseases. In particular, the frequency of circulating Tfh is correlated with disease activity and anti-DNA antibody titer in patients with systemic lupus erythematosus. Recent studies reveal functional diversity within the Tfh population in both humans and mice. We will summarize here the molecular mechanisms for Tfh cell generation, survival and function in both humans and mice, and the relationship between Tfh cells and autoimmune disease in animal models and in patients.

引用

页数：8

共 104 条

[1] Brief Report Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin-4 Levels and Plasmablast Numbers in IgG4-Related Disease [J].

Akiyama, Mitsuhiro ;

Suzuki, Katsuya ;

Yamaoka, Kunihiro ;

Yasuoka, Hidekata ;

Takeshita, Masaru ;

Kaneko, Yuko ;

Kondo, Harumi ;

Kassai, Yoshiaki ;

Miyazaki, Takahiro ;

Morita, Rimpei ;

Yoshimura, Akihiko ;

Takeuchi, Tsutomu .

ARTHRITIS & RHEUMATOLOGY, 2015, 67 (09) :2476-2481

[2] The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells [J].

Andris, Fabienne ;

Denanglaire, Sebastien ;

Anciaux, Maelle ;

Hercor, Melanie ;

Hussein, Hind ;

Leo, Oberdan .

FRONTIERS IN IMMUNOLOGY, 2017, 8

[3] Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus [J].

Arce, E ;

Jackson, DG ;

Gill, MA ;

Bennett, LB ;

Banchereau, J ;

Pascual, V .

JOURNAL OF IMMUNOLOGY, 2001, 167 (04) :2361-2369

[4] Constitutively altered frequencies of circulating follicullar helper T cell counterparts and their subsets in rheumatoid arthritis [J].

Arroyo-Villa, Irene ;

Bautista-Caro, Maria-Belen ;

Balsa, Alejandro ;

Aguado-Acin, Pilar ;

Bonilla-Hernan, Maria-Gema ;

Plasencia, Chamaida ;

Villalba, Alejandro ;

Nuno, Laura ;

Puig-Kroeger, Amaya ;

Martin-Mola, Emilio ;

Miranda-Carus, Maria-Eugenia .

ARTHRITIS RESEARCH & THERAPY, 2014, 16 (06)

[5] IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4 [J].

Avery, Danielle T. ;

Bryant, Vanessa L. ;

Ma, Cindy S. ;

Malefyt, Rene de Waal ;

Tangye, Stuart G. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (03) :1767-1779

[6] LONG-TERM HUMAN B-CELL LINES DEPENDENT ON INTERLEUKIN-4 AND ANTIBODY TO CD40 [J].

BANCHEREAU, J ;

DEPAOLI, P ;

VALLE, A ;

GARCIA, E ;

ROUSSET, F .

SCIENCE, 1991, 251 (4989) :70-72

[7] Restoring function in exhausted CD8 T cells during chronic viral infection [J].

Barber, DL ;

Wherry, EJ ;

Masopust, D ;

Zhu, BG ;

Allison, JP ;

Sharpe, AH ;

Freeman, GJ ;

Ahmed, R .

NATURE, 2006, 439 (7077) :682-687

[8] Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo [J].

Benson, Robert A. ;

MacLeod, Megan K. L. ;

Hale, Benjamin G. ;

Patakas, Agapitos ;

Garside, Paul ;

Brewer, James M. .

ELIFE, 2015, 4

[9] Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination [J].

Bentebibel, Salah-Eddine ;

Lopez, Santiago ;

Obermoser, Gerlinde ;

Schmitt, Nathalie ;

Mueller, Cynthia ;

Harrod, Carson ;

Flano, Emilio ;

Mejias, Asuncion ;

Albrecht, Randy A. ;

Blankenship, Derek ;

Xu, Hui ;

Pascual, Virginia ;

Banchereau, Jacques ;

Garcia-Sastre, Adolfo ;

Palucka, Anna Karolina ;

Ramilo, Octavio ;

Ueno, Hideki .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (176)

[10] Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers [J].

Bentebibel, Salah-Eddine ;

Schmitt, Nathalie ;

Banchereau, Jacques ;

Ueno, Hideki .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) :E488-E497

← 1 2 3 4 5 6 7 8 9 10 →