Coumarin-Based Turn-on Fluorescent Probe for Copper(II) Detection and Its Application in Cell Imaging

被引：4

作者：

Zhang Chang-Li ^{[1
]}

Zhang Hong ^{[1
]}

He Feng-Yun ^{[1
]}

Yang Hui ^{[1
]}

Liu Shao-Xian ^{[1
]}

Liu Min-Sheng ^{[1
]}

机构：

[1] Nanjing Xiaozhuang Univ, Sch Environm Sci, Key Lab Adv Funct Mat Nanjing, Nanjing 211171, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2019年 / 35卷 / 10期

关键词：

coumarin; copper probe; mechanism; cell imaging; CU2+ IONS; CHEMISTRY; PRION; CHEMODOSIMETER; NAPHTHALIMIDE; COORDINATION; CONSTRUCTION; CHEMOSENSORS; NEUROBIOLOGY; RECOGNITION;

D O I：

10.11862/CJIC.2019.207

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new coumarin-based Cu2+ probe (Cou-P) according to the Cu2+ coordination induced hydrolysis mechanism has been developed. Cou-P exhibits a highly selective turn -on response to Cu2+ over other transition metal ions in aqueous media. The recognition mechanism of Cou-P for Cu2+ was comfirmed by UV-Vis, fluorescence and mass spectrometry. The results show that Cou-P first forms Cou-P/Cu2+(1:1) complex, and Cou-P/Cu2+ complex is further catalyzed to 3 -(carboxylic acid)-7-(diethylamino)-coumarin (Cou-COOH) by excessive Cu2+. Cou-P has low cytotoxicity and good membrane permeability. It has been successfully used to detect Cu2+ in MCF-7 cells.

引用

页码：1869 / 1876

页数：8

共 53 条

[1] Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases [J].

Brown, DR ;

Kozlowski, H .

DALTON TRANSACTIONS, 2004, (13) :1907-1917

[2] Metals and neuroscience [J].

Bush, AI .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (02) :184-191

[3] Colorimetric and fluorescent pH and Cu2+ probes induced by photoisomerization of a maleonitrile-based Salen ligand [J].

Cheng, Jinghui ;

Zhang, Yuhui ;

Ma, Xiaofeng ;

Zhou, Xiangge ;

Xiang, Haifeng .

CHEMICAL COMMUNICATIONS, 2013, 49 (100) :11791-11793

[4] Zinc metabolism in the brain: Relevance to human neurodegenerative disorders [J].

Cuajungco, MP ;

Lees, GJ .

NEUROBIOLOGY OF DISEASE, 1997, 4 (3-4) :137-169

[5] A place for thioether chemistry in cellular copper ion recognition and trafficking [J].

Davis, Anna V. ;

O'Halloran, Thomas V. .

NATURE CHEMICAL BIOLOGY, 2008, 4 (03) :148-151

[6] Synthetic fluorescent sensors for studying the cell biology of metals [J].

Domaille, Dylan W. ;

Que, Emily L. ;

Chang, Christopher J. .

NATURE CHEMICAL BIOLOGY, 2008, 4 (03) :168-175

[7]

Fan FL, 2015, CHINESE J INORG CHEM, V31, P548

[8] The neurobiology of zinc in health and disease [J].

Frederickson, CJ ;

Koh, JY ;

Bush, AI .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (06) :449-462

[9] Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis) [J].

Gaggelli, Elena ;

Kozlowski, Henryk ;

Valensin, Daniela ;

Valensin, Gianni .

CHEMICAL REVIEWS, 2006, 106 (06) :1995-2044

[10] A reaction-based, colorimetric and near-infrared fluorescent probe for Cu2+ and its applications [J].

Gu, Biao ;

Huang, Liyan ;

Xu, Zhifeng ;

Tan, Zhen ;

Hu, Meng ;

Yang, Zitun ;

Chen, Yanxia ;

Peng, Cheng ;

Xiao, Wenpei ;

Yu, Donghai ;

Li, Haitao .

SENSORS AND ACTUATORS B-CHEMICAL, 2018, 273 :118-125

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