Balance and Imbalance in the Immune System: Life on the Edge

被引：25

作者：

Topalian, Suzanne L. ^{[1
]}

Sharpe, Arlene H. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21287 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

来源：

IMMUNITY | 2014年 / 41卷 / 05期

关键词：

T-CELL FUNCTION; CTLA-4;

D O I：

10.1016/j.immuni.2014.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.

引用

页码：682 / 684

页数：3

共 10 条

[1] Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4 [J].

Attia, P ;

Phan, GQ ;

Maker, AV ;

Robinson, MR ;

Quezado, MM ;

Yang, JC ;

Sherry, RM ;

Topalian, SL ;

Kammula, US ;

Royal, RE ;

Restifo, NP ;

Haworth, LR ;

Levy, C ;

Mavroukakis, SA ;

Nichol, G ;

Yellin, MJ ;

Rosenberg, SA .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (25) :6043-6053

[2] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

[3] Protein kinase C-η controls CTLA-4-mediated regulatory T cell function [J].

Kong, Kok-Fai ;

Fu, Guo ;

Zhang, Yaoyang ;

Yokosuka, Tadashi ;

Casas, Javier ;

Canonigo-Balancio, Ann J. ;

Becart, Stephane ;

Kim, Gisen ;

Yates, John R., III ;

Kronenberg, Mitchell ;

Saito, Takashi ;

Gascoigne, Nicholas R. J. ;

Altman, Amnon .

NATURE IMMUNOLOGY, 2014, 15 (05) :465-+

[4] Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4 [J].

Kuehn, Hye Sun ;

Ouyang, Weiming ;

Lo, Bernice ;

Deenick, Elissa K. ;

Niemela, Julie E. ;

Avery, Danielle T. ;

Schickel, Jean-Nicolas ;

Tran, Dat Q. ;

Stoddard, Jennifer ;

Zhang, Yu ;

Frucht, David M. ;

Dumitriu, Bogdan ;

Scheinberg, Phillip ;

Folio, Les R. ;

Frein, Cathleen A. ;

Price, Susan ;

Koh, Christopher ;

Heller, Theo ;

Seroogy, Christine M. ;

Huttenlocher, Anna ;

Rao, V. Koneti ;

Su, Helen C. ;

Kleiner, David ;

Notarangelo, Luigi D. ;

Rampertaap, Yajesh ;

Olivier, Kenneth N. ;

McElwee, Joshua ;

Hughes, Jason ;

Pittaluga, Stefania ;

Oliveira, Joao B. ;

Meffre, Eric ;

Fleisher, Thomas A. ;

Holland, Steven M. ;

Lenardo, Michael J. ;

Tangye, Stuart G. ;

Uzel, Gulbu .

SCIENCE, 2014, 345 (6204) :1623-1627

[5] Enhancement of antitumor immunity by CTLA-4 blockade [J].

Leach, DR ;

Krummel, MF ;

Allison, JP .

SCIENCE, 1996, 271 (5256) :1734-1736

[6]

Schubert D., 2014, NAT MED

[7] Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells [J].

Selby, Mark J. ;

Engelhardt, John J. ;

Quigley, Michael ;

Henning, Karla A. ;

Chen, Timothy ;

Srinivasan, Mohan ;

Korman, Alan J. .

CANCER IMMUNOLOGY RESEARCH, 2013, 1 (01) :32-42

[8]

Steinman L., 2014, EUR J IMMUNOL

[9] LOSS OF CTLA-4 LEADS TO MASSIVE LYMPHOPROLIFERATION AND FATAL MULTIORGAN TISSUE DESTRUCTION, REVEALING A CRITICAL NEGATIVE REGULATORY ROLE OF CTLA-4 [J].

TIVOL, EA ;

BORRIELLO, F ;

SCHWEITZER, AN ;

LYNCH, WP ;

BLUESTONE, JA ;

SHARPE, AH .

IMMUNITY, 1995, 3 (05) :541-547

[10] CTLA-4 control over Foxp3+ regulatory T cell function [J].

Wing, Kajsa ;

Onishi, Yasushi ;

Prieto-Martin, Paz ;

Yamaguchi, Tomoyuki ;

Miyara, Makoto ;

Fehervari, Zoltan ;

Nomura, Takashi ;

Sakaguchi, Shimon .

SCIENCE, 2008, 322 (5899) :271-275

← 1 →