Bridging Lung Development with Chronic Obstructive Pulmonary Disease Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis

被引:54
作者
Boucherat, Olivier [1 ]
Morissette, Mathieu C. [1 ]
Provencher, Steeve [1 ]
Bonnet, Sebastien [1 ]
Maltais, Francois [1 ]
机构
[1] Univ Laval, Ctr Rech, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada
关键词
emphysema; bronchopulmonary dysplasia; lung repair and regeneration; alveolar formation; lung homeostasis; ENDOTHELIAL GROWTH-FACTOR; GOBLET CELL METAPLASIA; HEDGEHOG-INTERACTING PROTEIN; SMOKE-INDUCED EMPHYSEMA; CIGARETTE-SMOKE; RETINOIC ACID; ALVEOLAR SEPTATION; GENE-EXPRESSION; RAT LUNG; TRANSFORMING GROWTH-FACTOR-BETA-1;
D O I
10.1164/rccm.201508-1518PP
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation. This generic term encompasses emphysema and chronic bronchitis, two common conditions, each having distinct but also overlapping features. Recent epidemiological and experimental studies have challenged the traditional view that COPD is exclusively an adult disease occurring after years of inhalational insults to the lungs, pinpointing abnormalities or disruption of the pathways that control lung development as an important susceptibility factor for adult COPD. In addition, there is growing evidence that emphysema is not solely a destructive process because it is also characterized by a failure in cell and molecular maintenance programs necessary for proper lung development. This leads to the concept that tissue regeneration required stimulation of signaling pathways that normally operate during development. We undertook a review of the literature to outline the contribution of developmental insults and genes in the occurrence and pathogenesis of COPD, respectively.
引用
收藏
页码:362 / 375
页数:14
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