Therapeutic potential of TGF-β inhibition in chronic renal failure

被引：36

作者：

Gagliardini, Elena ^{[1
]}

Benigni, Ariela ^{[1
]}

机构：

[1] Mario Negri Inst Pharmaceut Res, I-24125 Bergamo, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2007年 / 7卷 / 03期

关键词：

progressive nephropathies; proteinuria; renal fibrosis; transforming growth factor-beta;

D O I：

10.1517/14712598.7.3.293

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chronic kidney diseases are emerging as a worldwide public health problem. The progression of kidney diseases closely correlates with the accumulation of extracellular matrix leading to glomerulosclerosis and tubulointerstitial injury. Transforming growth factor (TGF)-beta has been identified as a key mediator of kidney matrix accumulation. Overexpression of TGF-beta isoforms and their receptors was observed in a variety of renal diseases in both animals and humans. Given its crucial role in fibrotic kidney disease, TGF-beta has been recently considered as a possible target in the management of chronic renal diseases. This review discusses the role of TGF-beta in renal fibrosis and provides an overview of the strategies that, when interfering with TGF-beta expression and signalling, could be employed as new renoprotective treatments.

引用

页码：293 / 304

页数：12

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