Complete assignments of the 1H and 13C resonances of 40-epi-(N1-tetrazolyl)rapamycin and revised 13C assignments for rapamycin

被引：11
|
作者：
Pagano, TG [1 ]
机构：
[1] Abbott Labs, Global Pharmaceut R&D Div, Abbott Pk, IL 60064 USA
来源：
MAGNETIC RESONANCE IN CHEMISTRY | 2005年 / 43卷 / 02期
关键词：
NMR; H-1; C-13; two-dimensional NMR; rapamycin; 40-epi-(N1-tetrazolyl)-rapamycin; ABT-578;
D O I：
10.1002/mrc.1524
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Complete H-1 and C-13 assignments of 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578) in DMSO-d(6) were made using H-1, C-13, DQCOSY, ROESY, TOCSY, HSQC and HMBC spectra. Comparing the assignments with those of rapamycin showed that in the published C-13 assignments of rapamycin in DMSO-d(6) the shifts for C-12 and C-42 have been interchanged, as well as the shifts for C-1 and C-8. Copyright (C) 2004 John Wiley Sons, Ltd.
引用
收藏
页码：174 / 175
页数：2
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