Escherichia coli as a host for metabolic engineering

被引：247
作者：
Pontrelli, Sammy [1 ]
Chiu, Tsan-Yu [2 ]
Lan, Ethan I. [3 ]
Chen, Frederic Y. -H. [1 ,2 ]
Chang, Peiching [4 ,5 ]
Liao, James C. [2 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA USA
[2] Acad Sinica, Inst Biol Chem, Taipei, Taiwan
[3] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan
[4] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu, Taiwan
[5] Ind Technol Res Inst, Mat & Chem Res Labs, Hsinchu, Taiwan
来源：
METABOLIC ENGINEERING | 2018年 / 50卷
关键词：
HIGH-LEVEL EXPRESSION; HIGH-YIELD PRODUCTION; MICROBIAL-PRODUCTION; ZYMOMONAS-MOBILIS; SUCCINATE PRODUCTION; PROTEIN ACETYLATION; ENHANCED PRODUCTION; SYNTHETIC BIOLOGY; RNA-POLYMERASE; ITACONIC ACID;
D O I：
10.1016/j.ymben.2018.04.008
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Over the past century, Escherichia coli has become one of the best studied organisms on earth. Features such as genetic tractability, favorable growth conditions, well characterized biochemistry and physiology, and availability of versatile genetic manipulation tools make E. coli an ideal platform host for development of industrially viable productions. In this review, we discuss the physiological attributes of E. coli that are most relevant for metabolic engineering, as well as emerging techniques that enable efficient phenotype construction. Further, we summarize the large number of native and non-native products that have been synthesized by E. coli, and address some of the future challenges in broadening substrate range and fighting phage infection.
引用
收藏
页码：16 / 46
页数：31
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