Polyethylene glycol (PEG-400): an efficient green reaction medium for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones under catalyst-free conditions

被引：27
|
作者：
Reddy, Mudumala Veeranarayana [1 ]
Kim, Jong Su [1 ]
Lim, Kwon Taek [1 ]
Jeong, Yeon Tae [1 ]
机构：
[1] Pukyong Natl Univ, Dept Image Sci & Engn, Pusan 608737, South Korea
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 47期
关键词：
Polyethylene glycol (PEG-400); Benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones; 1H-Benzo[d]imidazol-2-amine; Catalyst-free conditions; ONE-POT SYNTHESIS; HIGHLY EFFICIENT; SOLVENT-FREE; MULTICOMPONENT SYNTHESIS; ALPHA-AMINOPHOSPHONATES; DERIVATIVES; INHIBITORS; WATER; ACID; RING;
D O I：
10.1016/j.tetlet.2014.09.135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and an efficient eco-friendly methodology has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones in excellent yields under catalyst-free-conditions using inexpensive and non-toxic polyethylene glycol (PEG-400) medium. This new protocol offers an environmental acceptability, shorter reaction time, room temperature, low cost, high yields, and recyclability of the PEG-400 medium are the important features. This method provides a green and much improved protocol over the existing methods. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6459 / 6462
页数：4
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