Polyethylene glycol (PEG-400): an efficient green reaction medium for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones under catalyst-free conditions

被引：27

作者：

Reddy, Mudumala Veeranarayana ^{[1
]}

Kim, Jong Su ^{[1
]}

Lim, Kwon Taek ^{[1
]}

Jeong, Yeon Tae ^{[1
]}

机构：

[1] Pukyong Natl Univ, Dept Image Sci & Engn, Pusan 608737, South Korea

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 47期

关键词：

Polyethylene glycol (PEG-400); Benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones; 1H-Benzo[d]imidazol-2-amine; Catalyst-free conditions; ONE-POT SYNTHESIS; HIGHLY EFFICIENT; SOLVENT-FREE; MULTICOMPONENT SYNTHESIS; ALPHA-AMINOPHOSPHONATES; DERIVATIVES; INHIBITORS; WATER; ACID; RING;

D O I：

10.1016/j.tetlet.2014.09.135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and an efficient eco-friendly methodology has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones in excellent yields under catalyst-free-conditions using inexpensive and non-toxic polyethylene glycol (PEG-400) medium. This new protocol offers an environmental acceptability, shorter reaction time, room temperature, low cost, high yields, and recyclability of the PEG-400 medium are the important features. This method provides a green and much improved protocol over the existing methods. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6459 / 6462

页数：4

共 50 条

[1] A catalyst-free reaction in water: synthesis of benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives
Liu, Junhua
Lei, Min
Hu, Lihong
GREEN CHEMISTRY, 2012, 14 (09) : 2534 - 2539
[2] Copper-Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones using Cyanamide as a Building Block
Lou, Zhenbang
Wu, Xudong
Yang, Haijun
Zhu, Changjin
Fu, Hua
ADVANCED SYNTHESIS & CATALYSIS, 2015, 357 (18) : 3961 - 3968
[3] Synthesis of benzo[4,5] imidazo[ 1,2-a] pyrimidines and 2,3-dihydroquinazolin-4( 1H)- ones under metal- free and solvent- free conditions for minimizing waste generation
Phuong Hoang Tran
Thanh-Phuong Thi Bui
Xuan-Quynh Bach Lam
Xuan-Trang Thi Nguyen
RSC ADVANCES, 2018, 8 (63): : 36392 - 36399
[4] Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo [1,2-a]pyrimidin-4-ones
Puttaraju, Kallimeledoddi B.
Shivashankar, Kalegowda
Chandra
Mahendra, M.
Rasal, Vijaykumar P.
Vivek, Ponnuru N. Venkata
Rai, Khushboo
Chanu, Maibam Beebina
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 69 : 316 - 322
[5] Synthesis of α1-oxindole-α-hydroxyphosphonates under catalyst-free conditions using polyethylene glycol (PEG-400) as an efficient and recyclable reaction medium
Nagarapu, Lingaiah
Mallepalli, Raghu
Kumar, U. Nikhil
Venkateswarlu, P.
Bantu, Rajashaker
Yeramanchi, Lingappa
TETRAHEDRON LETTERS, 2012, 53 (14) : 1699 - 1700
[6] Design and Synthesis of Pyrimido [4,5-d]pyrimidin-4(3H)-ones as Selective L3MBTL1 Binders
Zhou Hao
Che Xin
Peng Li
Wang Na
Bai Xu
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2016, 37 (07): : 1293 - 1301
[7] One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-2-ones Using a Hybrid Catalyst Supported on Magnetic Nanoparticles in Green Solvents
Moussa, Alkassoume
Rahmati, Abbas
CHEMISTRYOPEN, 2021, 10 (08) : 764 - 774
[8] Biginelli Synthesis of Regioisomeric 5,6-Dihydro-4H-benzo[4,5]imidazo[1,2-a]pyranopyrimidin-4-ones
Kanevskaya, I. V.
Bondartsova, A. S.
Fedotova, O. V.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (10) : 1753 - 1757
[9] Biginelli Synthesis of Regioisomeric 5,6-Dihydro-4H-benzo[4,5]imidazo[1,2-a]pyranopyrimidin-4-ones
I. V. Kanevskaya
A. S. Bondartsova
O. V. Fedotova
Russian Journal of Organic Chemistry, 2020, 56 : 1753 - 1757
[10] Synthesis and antimicrobial evaluation of imidazo-[1',5':1,2]pyrimido [4,5-d]isoxazolo[2,3-a]pyrimidin-10-ones
Sanjeev, Rella
Dongarkadekar, P., V
Swami, Mahesh Bapurao
INDIAN JOURNAL OF CHEMISTRY, 2023, 62 (12): : 1303 - 1312

← 1 2 3 4 5 →