There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases

被引：351

作者：

Paillusson, Sebastien ^{[1
]}

Stoica, Radu ^{[1
]}

Gomez-Suaga, Patricia ^{[1
]}

Lau, Dawn H. W. ^{[1
]}

Mueller, Sarah ^{[1
]}

Miller, Tanya ^{[2
]}

Miller, Christopher C. J. ^{[1
]}

机构：

[1] Kings Coll London, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London SE5 9NU, England

[2] Churchill Hosp, Old Rd, Oxford OX3 7LE, England

来源：

TRENDS IN NEUROSCIENCES | 2016年 / 39卷 / 03期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

MOTOR-NEURON DEGENERATION; ENDOPLASMIC-RETICULUM; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; AXONAL-TRANSPORT; CALCIUM HOMEOSTASIS; ALPHA-SYNUCLEIN; TAU PHOSPHORYLATION; VAPB INTERACTS; CONTACT SITES;

D O I：

10.1016/j.tins.2016.01.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with associated frontotemporal dementia (ALS/FTD) are major neuro-degenerative diseases for which there are no cures. All are characterised by damage to several seemingly disparate cellular processes. The broad nature of this damage makes understanding pathogenic mechanisms and devising new treatments difficult. Can the different damaged functions be linked together in a common disease pathway and which damaged function should be targeted for therapy? Many functions damaged in neurodegenerative diseases are regulated by communications that mitochondria make with a specialised region of the endoplasmic reticulum (ER; mitochondria-associated ER membranes or 'MAM'). Moreover, several recent studies have shown that disturbances to ER-mitochondria contacts occur in neurodegenerative diseases. Here, we review these findings.

引用

页码：146 / 157

页数：12

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