A highly efficient tandem [3+2] "click" cycloaddition/6-exo-cyclization strategy for the construction of triazole fused pyrazines

被引：19

作者：

Roy, Biswajit ^{[1
]}

Mondal, Debashis ^{[1
]}

Hatai, Joydev ^{[1
]}

Bandyopadhyay, Subhajit ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Kolkata, Nadia 741246, WB, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 100期

关键词：

SODIUM-AZIDE; AMINO-ACID; ALKYNES; RULES; ISOCYANIDES; DERIVATIVES;

D O I：

10.1039/c4ra12489h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pharmaceutically important tetrahydro-[1,2,3] triazolopyrazine heterocyclic architecture has been synthesized via a concise tandem "click"/6-exo-dig cyclization strategy in mixed aqueous-organic media. The generality of this mild method was expanded to various amino acid based substrates. The scopes and limitations of this method are discussed in the paper.

引用

收藏

页码：56952 / 56956

页数：5

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