Vanadium-Catalyzed Solvent-Free Synthesis of Quaternary α-Trifluoromethyl Nitriles by Electrophilic Trifluoromethylation

被引：42

作者：

Frueh, Natalja ^{[1
]}

Togni, Antonio ^{[1
]}

机构：

[1] ETH, Dept Chem & Angew Biowissensch, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 40期

关键词：

nitriles; quaternary centers; solvent-free processes; trifluoromethylation; vanadium; SILYL KETENE IMINES; ASYMMETRIC-SYNTHESIS; OXYTRIFLUOROMETHYLATION; NUCLEOPHILES; REAGENTS;

D O I：

10.1002/anie.201406181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct electrophilic trifluoromethylation of silyl ketene imines (SKIs) with hypervalent iodine reagents leads to the formation of quaternary alpha-trifluoromethyl nitriles in good yields. This new reaction has been carried out with a variety of substituted SKIs under solvent-free conditions using a vanadium(IV) catalyst (5 mol%). The corresponding products may be transformed into useful organofluorine building blocks.

引用

页码：10813 / 10816

页数：4

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