Hypersampsones S-W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

被引：19
|
作者：
Tian, Wen-Jing [1 ,3 ]
Qiu, Yu-Qin [2 ]
Jin, Xiao-Jie [4 ]
Chen, Hai-Feng [1 ]
Yao, Xiao-Jun [4 ,5 ]
Dai, Yi [2 ]
Yao, Xin-Sheng [2 ,3 ]
机构：
[1] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China
[3] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[4] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
[5] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 56期
关键词：
POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; SKELETON; CORES;
D O I：
10.1039/c5ra26332h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Five new polycyclic polyprenylated acylphloroglucinols (1-5) with a bicyclo[3.3.1] nonane skeleton, along with five known analogues (6-10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1-5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXR alpha transcriptional-inhibitory activities and cytotoxicity against HeLa cells.
引用
收藏
页码：50887 / 50894
页数：8
相关论文
共 36 条
  • [1] Novel polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii
    Tian, Wen-Jing
    Qiu, Yu-Qin
    Jin, Xiao-Jie
    Chen, Hai-Feng
    Yao, Xiao-Jun
    Dai, Yi
    Yao, Xin-Sheng
    TETRAHEDRON, 2014, 70 (43) : 7912 - 7916
  • [2] Polycyclic polyprenylated acylphloroglucinols: natural phosphodiesterase-4 inhibitors from Hypericum sampsonii
    Zhang, Jun-Sheng
    Zou, Yi-Hong
    Guo, Yan-Qiong
    Li, Zhen-Zhen
    Tang, Gui-Hua
    Yin, Sheng
    RSC ADVANCES, 2016, 6 (58): : 53469 - 53476
  • [3] Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii
    Zhu, Hucheng
    Chen, Chunmei
    Tong, Qingyi
    Chen, Xintao
    Yang, Jing
    Liu, Junjun
    Sun, Bin
    Wang, Jianping
    Yao, Guangmin
    Luo, Zengwei
    Xue, Yongbo
    Zhang, Yonghui
    SCIENTIFIC REPORTS, 2015, 5
  • [4] Norsampsones A-D, Four New Decarbonyl Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii
    Tian, Wen-Jing
    Yu, Yang
    Yao, Xiao-Jun
    Chen, Hai-Feng
    Dai, Yi
    Zhang, Xiao-Kun
    Yao, Xin-Sheng
    ORGANIC LETTERS, 2014, 16 (13) : 3448 - 3451
  • [5] Cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum attenuatum
    Zhou, Zhong-bo
    Zhang, Yang-mei
    Pan, Ke
    Luo, Jian-guang
    Kong, Ling-yi
    FITOTERAPIA, 2014, 95 : 1 - 7
  • [6] Polycyclic polyprenylated acylphloroglucinols from Hypericum choisianum
    Zhang, Hai-Bo
    Zhang, Xu
    Jiang, Kun
    Qu, Shi-Jin
    Meng, Ling-Hua
    Lu, Qun
    Tan, Chang-Heng
    NATURAL PRODUCT RESEARCH, 2021, 35 (02) : 195 - 202
  • [7] Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum scabrum
    Zhou, Zhong-Bo
    Mou, Peng-Yun
    Huang, You-Yi
    Zeng, Hong
    Huang, Zu-Liang
    Wei, Xian
    FITOTERAPIA, 2022, 161
  • [8] Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity
    Ma, Yonghui
    Suo, Xinyue
    Li, Xiaoxiu
    Zhu, Tingting
    Li, Jin
    Ji, Tengfei
    Liu, Bo
    PHYTOCHEMISTRY, 2022, 203
  • [9] homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum
    Ye, Ye
    Yang, Xing-Wei
    Zhou, Yan
    Xu, Gang
    FITOTERAPIA, 2019, 133 : 43 - 50
  • [10] Novel Polyprenylated Phloroglucinols from Hypericum sampsonii
    Chen, Jih-Jung
    Chen, Hong-Jhang
    Lin, Yun-Lian
    MOLECULES, 2014, 19 (12) : 19836 - 19844
1234