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Yonsei Univ, Coll Med, Dept Prevent Med, Integrat Res Ctr Cerebrovasc & Cardiovasc Dis, 50-1 Yonsei Ro, Seoul 03722, South Korea Yonsei Univ, Coll Med, Dept Prevent Med, Integrat Res Ctr Cerebrovasc & Cardiovasc Dis, 50-1 Yonsei Ro, Seoul 03722, South Korea