Copper-catalyzed four-component reaction of alkenes, Togni's reagent, amines and CO2: stereoselective synthesis of (Z)-enol carbamates

A copper-catalyzed four-component reaction of alkenes, Togni's reagent, amines and CO2 has been successfully developed for the first time, which provides an efficient and straightforward method for the synthesis of a range of stereodefined (Z)-enol carbamates. Easily available starting materials and cheap catalyst, high stereoselectivity, good functional group tolerance and broad substrate scope are the features of the transformation. The mechanistic aspects of this transformation have been elucidated by control experiments and density functional theory calculations.