Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

被引：50

作者：

Corvino, Angela ^{[1
]}

Frecentese, Francesco ^{[1
]}

Magli, Elisa ^{[1
]}

Perissutti, Elisa ^{[1
]}

Santagada, Vincenzo ^{[1
]}

Scognamiglio, Antonia ^{[1
]}

Caliendo, Giuseppe ^{[1
]}

Fiorino, Ferdinando ^{[1
]}

Severino, Beatrice ^{[1
]}

机构：

[1] Univ Naples Federico II, Sch Med, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 03期

关键词：

hydrogen sulfide; natural H2S donors; synthetic H2S donors; triggered mechanism; H2S release; cardiovascular diseases; HYDROGEN-SULFIDE DONOR; NITRIC-OXIDE BIOAVAILABILITY; ISCHEMIA-REPERFUSION INJURY; INDUCED HEART-FAILURE; S-ALLYL CYSTEINE; MYOCARDIAL-ISCHEMIA; OXIDATIVE STRESS; H2S DONORS; ISCHEMIA/REPERFUSION INJURY; MEDIATES CARDIOPROTECTION;

D O I：

10.3390/antiox10030429

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen sulfide (H2S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a significant role in many physio-pathological processes, such as inflammation, oxidation, neurophysiology, ion channels regulation, cardiovascular protection, endocrine regulation, and tumor progression. Considering the plethora of physiological effects of this gasotransmitter, the protective role of H2S donors in different disease models has been extensively studied. Based on the growing interest in H2S-releasing compounds and their importance as tools for biological and pharmacological studies, this review is an exploration of currently available H2S donors, classifying them by the H2S-releasing-triggered mechanism and highlighting those potentially useful as promising drugs in the treatment of cardiovascular diseases.

引用

页码：1 / 27

页数：27