Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux

被引：10
作者：
Hsu, Chih-Peng [1 ]
Lin, Chih-Hung [2 ]
Kuo, Chan-Yen [3 ,4 ]
机构：
[1] Chang Bing Show Chwan Mem Hosp, Dept Cardiol, Changhua, Taiwan
[2] Cathay Gen Hosp, Dept Internal Med, Taipei, Taiwan
[3] Natl Cent Univ, Grad Inst Syst Biol & Bioinformat, Chungli, Taiwan
[4] Hsin Sheng Jr Coll Med Care & Management, Dept Ophthalmol, Longtan, Taiwan
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2018年 / 15卷 / 10期
关键词：
Propofol; cholesterol efflux; reactive oxygen species; inflammation; high-density lipoprotein; rat aortic endothelial cells; ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS; FOAM CELLS; ABCA1; ATHEROSCLEROSIS; CAVEOLIN-1; DYSFUNCTION; MECHANISM;
D O I：
10.7150/ijms.24659
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Cholesterol efflux efficiency, reactive oxygen species, and inflammation are closely related to cardiovascular diseases. Our aim was to investigate the effect of propofol on cholesterol-loaded rat aortic endothelial cells after high-density lipoprotein treatment in vitro. Methods and Results: The results showed that propofol promoted cholesterol efflux and ameliorated inflammation and reactive oxygen species overproduction according to the analysis of p65 nuclear translocation and a 2',7'-dichlorofluorescin diacetate assay, respectively. Conclusions: These results provide a possible explanation for the anti-inflammatory, antioxidant, and cholesterol efflux-promoting effects of propofol on rat aortic endothelial cells after incubation with high-density lipoprotein.
引用
收藏
页码：978 / 985
页数：8
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