Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays

被引：17

作者：

Qiu, Jie ^{[1
]}

Hong, Qin ^{[1
]}

Chen, Rong-hua ^{[2
]}

Tong, Mei-ling ^{[1
,2
]}

Zhang, Min ^{[1
,2
]}

Fei, Li ^{[2
]}

Pan, Xiao-qin ^{[2
]}

Guo, Mei ^{[2
]}

Guo, Xi-rong ^{[1
,2
]}

Chi, Xia ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Dept Pediat, Nanjing Matern & Child Hlth Hosp, Nanjing 210004, Peoples R China

[2] Nanjing Med Univ, Inst Pediat, Nanjing 210029, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2010年 / 37卷 / 04期

基金：

中国国家自然科学基金;

关键词：

cDNA microarrays; ADHD; SHR; WKY; Prefrontal cortex; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; SPONTANEOUSLY HYPERTENSIVE-RAT; METABOTROPIC GLUTAMATE RECEPTORS; ANIMAL-MODEL; DOPAMINE TRANSPORTER; MESSENGER-RNA; NGFI-B; ADHD; ASSOCIATION;

D O I：

10.1007/s11033-009-9596-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD.

引用

页码：1733 / 1740

页数：8

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