Chitosan and its derivatives: vectors in gene therapy

被引：66
作者：
Kritchenkov, Andrey S. [1 ,2 ]
Andranovits, Stanislav [3 ]
Skorik, Yury A. [1 ,4 ]
机构：
[1] Russian Acad Sci, Inst Macromol Cpds, Lab Nat Polymers, Bolshoi Prosp VO 31, St Petersburg 199004, Russia
[2] St Petersburg State Univ, Inst Chem, Lab Biomed Chem, Univ Skii Prosp 26, St Petersburg 198504, Russia
[3] Univ Vienna, Dept Pharmacol & Toxicol, Althanstrsse 14, A-1090 Vienna, Austria
[4] Fed VA Almazov North West Med Res Ctr, Inst Expt Med, Div Analyt Chem, Ul Akkuratova 2, St Petersburg 197341, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2017年 / 86卷 / 03期
基金：
俄罗斯基础研究基金会;
关键词：
ADMINISTRATION IN-VIVO; ACID-MODIFIED CHITOSAN; DRUG-DELIVERY SYSTEM; TRANSFECTION EFFICIENCY; DNA NANOPARTICLES; QUATERNIZED CHITOSAN; MOLECULAR-WEIGHT; SIRNA DELIVERY; PHYSICOCHEMICAL PROPERTIES; VITRO TRANSFECTION;
D O I：
10.1070/RCR4636
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The review deals with the use of chitosan and its derivatives as vectors for delivery of nucleic acids in gene therapy. Factors influencing the transfection efficiency of chitosan-based polyplexes (molecular weight, the degree of deacetylation, pH, type of chemical modification, type of transfected cells) are discussed. Particular attention is paid to methods of chemical modification of chitosan (covalent hydrophilic and hydrophobic modification and non-covalent modification), which are able to increase the transfection efficiency and to provide targeted delivery of nucleic acids.
引用
收藏
页码：231 / 239
页数：9
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