Brain Tumors in Children

被引:49
作者
Cohen, Alan R. [1 ,2 ]
机构
[1] Johns Hopkins Univ, Dept Neurosurg, Sch Med, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Phipps Bldg,Rm 556,600 N Wolfe St, Baltimore, MD 21287 USA
关键词
CENTRAL-NERVOUS-SYSTEM; MAPK PATHWAY ACTIVATION; HIGH-GRADE GLIOMAS; MOLECULAR SUBGROUPS; PROGNOSTIC-FACTORS; LONG-TERM; MEDULLOBLASTOMA; CHILDHOOD; MUTATIONS; CLASSIFICATION;
D O I
10.1056/NEJMra2116344
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Brain Tumors in ChildrenChildhood brain tumors were previously classified by histologic appearance and location. A new classification includes genetic changes, which have prognostic significance and may lead to therapeutic targets. This review focuses on pediatric gliomas, ependymomas, and medulloblastomas.
引用
收藏
页码:1922 / 1931
页数:10
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