Application of Optogenetics in The Regulation of Bacterial Life Activities

被引:0
|
作者
Mao Shi-Di [1 ]
Ma Zi-Dong [1 ]
Ma Bin-Guang [1 ]
机构
[1] Huazhong Agr Univ, Coll Informat, Wuhan 430070, Peoples R China
基金
中国国家自然科学基金;
关键词
optogenetics; bacteria; gene regulation; synthetic biology; ENGINEERING ESCHERICHIA-COLI; GENE-EXPRESSION; LIGHT; DEGRADATION; RECEPTORS; DESIGN;
D O I
10.16476/j.pibb.2020.0210
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Using light as input signal, optogenetics technology can precisely regulate the physiological functions of cells and has high specificity of time and space, which makes it possible to construct highly dynamic regulatory system. In recent years, with the discovery of novel photosensitive proteins and the innovation of light systems, the efficiency of optogenetics-based light control systems has been significantly improved. The application of light control system in bacteria is becoming more and more extensive. By using the lightcontrol system as an input module and combining it with other biological function modules, the regulation of gene expression, protein activity and bacterial physiological function can be realized. This paper mainly introduces the basic principle of optogenetics and its application in synthetic biology and the regulation of bacterial life activities.
引用
收藏
页码:369 / 377
页数:9
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