The eastern Tianshan is an important part of the accretionary Central Asian Orogenic Belt ( CAOB), where the eastern Tianshan Paleozoic arc-basin system was developed during the formation, evolution and closure of the Paleo-Asian Ocean. Based on a large number of the predecessors' studies on Paleozoic tectonic evolution and metallogenic regularity of the eastern Tianshan, and aimed at the relatively weakness upon researches in the past about Early Paleozoic tectonic evolution and metallogenesis, this paper focuses on the new progress of the Early Paleozoic tectonic-magmatic-metallogenic studies in the Kalatage ore cluster area, and further discusses the Paleozoic tectonic evolution and metallogenic regularity of the paleo arc-basin system of eastern Tianshan. In this paper, the Paleozoic arc-basin system of the eastern Tianshan is divided into two metallogenic belts of Dananhu-Tousuquan and AqishanYamansu, while the former is further divided into the Kalatage and the Xiaorequanzi-Tuwu metallogenic sub-belts. It is concluded that this paleo arc-basin system has coexistence of VMS and porphyry metallogenic stystems. Multiple types of superimposed mineralization are widely developed in these systems. Tectonically, two large-scale metallogenic events have been developed, and both of them are related to large-scale volcanic-intrusive magmatic activities. Finally, a regional metallogenic model of the paleo arc-basin system of the eastern Tianshan is constructed, in which we propose that the multi-directional and multi-stage transformation of Paleozoic arc and basin in the eastern Tianshan is the main reason for the coexistence of VMS-porphyry deposits and superimposed mineralization in this system.