The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

被引：30

作者：

Nokhodchi, A

Nazemiyeh, H

Ghafourian, T

Hassan-Zadeh, D

Valizadeh, H

Bahary, LAS

机构：

[1] Sch Hlth & Life Sci, Dept Pharm, London SE1 9NN, England

[2] Tabriz Med Sci Univ, Sch Pharm, Tabriz, Iran

来源：

FARMACO | 2002年 / 57卷 / 11期

关键词：

skin penetration; enhancer; glycyrrhizin; release rate; diclofenac sodium;

D O I：

10.1016/S0014-827X(02)01298-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethlcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1% w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：883 / 888

页数：6

共 26 条

[1]

AFCHAR D, 1992, J SCH PHARM TEHRAN U, V2, P229

[2]

AFCHAR D, 1981, THESIS U PARIS SUD

[3] Enhancing effect of terpenes on the in vitro percutaneous absorption of diclofenac sodium. [J].