A critical appraisal of "Shingrix', a novel herpes zoster subunit vaccine (HZ/Su or GSK1437173A) for varicella zoster virus

被引：45

作者：

Bharucha, Tehmina ^{[1
]}

Ming, Damien ^{[2
]}

Breuer, Judith ^{[1
,3
]}

机构：

[1] UCL, Div Infect & Immun, Cruciform Bldg, London WC1E 6BT, England

[2] Imperial Coll London, Dept Infect Dis & Immun, London, England

[3] Great Ormond St Hosp Sick Children, Microbiol Virol & Infect Control, London, England

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2017年 / 13卷 / 08期

关键词：

immunisation; vaccination; public health; shingles; varicella; herpes zoster virus; CANDIDATE VACCINE; IMMUNE-RESPONSES; TERM PERSISTENCE; LONG-TERM; IMMUNOGENICITY; SAFETY; ADULTS; EFFICACY; GLYCOPROTEINS; INFECTION;

D O I：

10.1080/21645515.2017.1317410

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

HZ/Su, branded as Shingrix', is one of the newest vaccines to be submitted for multi-national regulatory approval. It is targeted to prevent shingles, a global concern with aging populations. A live attenuated vaccine for shingles has been available for over a decade, however it is contraindicated in specific subgroups of people, and there are added concerns regarding long-term immunogenicity. HZ/Su is the first subunit vaccine developed to protect against shingles. This paper provides a critical appraisal of current evidence regarding HZ/Su.

引用

页码：1789 / 1797

页数：9

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