Recent advances in breast cancer biology

被引:4
作者
Unger, MA
Weber, BL
机构
[1] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
关键词
D O I
10.1097/00001622-200011000-00002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and navel genes that may contribute to breast tumorigenesis have been discovered, In addition, unique animal models and improvements in gene expression profiling technology have given researchers new tools to address previously unanswerable questions about this disease, Curr Opin Oncol 2000, 12:521-525 (C) 2000 Lippincott Williams & Wilkins, Inc.
引用
收藏
页码:521 / 525
页数:5
相关论文
共 51 条
[1]   Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis [J].
Andrechek, ER ;
Hardy, WR ;
Siegel, PM ;
Rudnicki, MA ;
Cardiff, RD ;
Muller, WJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3444-3449
[2]   Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer [J].
Athma, P ;
Rappaport, R ;
Swift, M .
CANCER GENETICS AND CYTOGENETICS, 1996, 92 (02) :130-134
[3]   Role of the human RAD51 protein in homologous recombination and double-stranded break repair [J].
Baumann, P ;
West, SC .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (07) :247-251
[4]   Expression scanning of an array of growth control genes in human tumor cell lines [J].
Bertucci, F ;
Van Hulst, S ;
Bernard, K ;
Loriod, B ;
Granjeaud, S ;
Tagett, R ;
Starkey, M ;
Nguyen, C ;
Jordan, B ;
Birnbaum, D .
ONCOGENE, 1999, 18 (26) :3905-3912
[5]  
Boggio K, 2000, CANCER RES, V60, P359
[6]   Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1 [J].
Chan, GKT ;
Schaar, BT ;
Yen, TJ .
JOURNAL OF CELL BIOLOGY, 1998, 143 (01) :49-63
[7]   Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G2/M checkpoint control [J].
Chen, CF ;
Chen, PL ;
Zhong, Q ;
Sharp, ZD ;
Lee, WH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :32931-32935
[8]   Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells [J].
Chen, JJ ;
Silver, DP ;
Walpita, D ;
Cantor, SB ;
Gazdar, AF ;
Tomlinson, G ;
Couch, FJ ;
Weber, BL ;
Ashley, T ;
Livingston, DM ;
Scully, R .
MOLECULAR CELL, 1998, 2 (03) :317-328
[9]   The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment [J].
Chen, PL ;
Chen, CF ;
Chen, YM ;
Xiao, J ;
Sharp, ZD ;
Lee, WH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :5287-5292
[10]   Making and reading microarrays [J].
Cheung, VG ;
Morley, M ;
Aguilar, F ;
Massimi, A ;
Kucherlapati, R ;
Childs, G .
NATURE GENETICS, 1999, 21 (Suppl 1) :15-19