Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides

被引：0
|
作者：
Singh, Anamika [1 ]
Haslach, Erica M. [1 ]
Haskell-Luevano, Carrie [1 ]
机构：
[1] Univ Florida, Dept Pharmacodynam, Gainesville, FL 32610 USA
来源：
MELANOCORTINS: MULTIPLE ACTIONS AND THERAPEUTIC POTENTIAL | 2010年 / 681卷
关键词：
MELANOCYTE-STIMULATING-HORMONE; GAMMA-MSH ANALOGS; ALPHA-MELANOTROPIN; TETRAPEPTIDE AC-HIS-DPHE-ARG-TRP-NH2; MOLECULAR-CLONING; PROTEIN AGRP; BIOLOGICAL EVALUATION; AND-4; RECEPTORS; INVERSE AGONIST; HIGHLY POTENT;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Structure-activity relationship (SAR) studies are a key feature of peptide and peptidomimetic research to improve the biological properties of native peptides and convert them into more drug-like compounds. Peptide SAR studies involve the systematic modification of a lead peptide to provide insight into the molecular determinants of the ligand-receptor interactions that result in either receptor stimulation or inhibition. This chapter will discuss structure-activity relationships of the endogenous and synthetic agonists and the antagonists of the melanocortin system.
引用
收藏
页码：1 / 18
页数：18
相关论文
共 50 条
  • [1] Conformational studies of agouti-related protein (AGRP)-melanocortin chimeric peptides
    Wilczynski, A
    Wilson, KR
    Scott, JW
    Edison, AS
    Haskell-Luevano, C
    BIOPOLYMERS, 2005, 80 (04) : 553 - 553
  • [2] Conformational studies of agouti-related protein (AGRP)-melanocortin chimeric peptides
    Wilczynski, Andrzej
    Wilson, Krista R.
    Scott, Joseph W.
    Edison, Arthur S.
    Haskell-Luevano, Carrie
    UNDERSTANDING BIOLOGY USING PEPTIDES, 2006, : 381 - +
  • [3] Current trends in the structure activity relationship studies of the endogenous agouti-related protein (AGRP) melanocortin receptor antagonist
    Wilczynski, AM
    Joseph, CG
    Haskell-Luevano, C
    MEDICINAL RESEARCH REVIEWS, 2005, 25 (05) : 545 - 556
  • [4] Structure and function studies of a bicyclic Agouti-related protein (AGRP) melanocortin-4 receptor antagonist
    Wilczynski, Andrzej
    Wang, Xiang S.
    Bauzo, Rayna M.
    Thirumoorthy, Ramanan
    Xiang, Zhimin
    Edison, Arthur S.
    Richards, Nigel G. J.
    Haskell-Luevano, Carrie
    PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS, 2004, : 565 - 566
  • [5] Structure and function studies of a bicyclic agouti-related protein (AGRP) melanocortin-4 receptor antagonist
    Wilczynski, A
    Bauzo, RM
    Edison, AS
    Thirumoorthy, R
    Haskell-Luevano, C
    BIOPOLYMERS, 2003, 71 (03) : 373 - 373
  • [6] Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken
    Takeuchi, S
    Teshigawara, K
    Takahashi, S
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2000, 1496 (2-3): : 261 - 269
  • [7] Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity
    Joseph, CG
    Wilczynski, A
    Holder, JR
    Xiang, ZM
    Bauzo, RM
    Scott, JW
    Haskell-Luevano, C
    PEPTIDES, 2003, 24 (12) : 1899 - 1908
  • [8] Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis:: Identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants
    Haskell-Luevano, C
    Cone, RD
    Monck, EK
    Wan, YP
    BIOCHEMISTRY, 2001, 40 (20) : 6164 - 6179
  • [9] Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation
    Bures, EJ
    Hui, JO
    Young, Y
    Chow, DT
    Katta, V
    Rohde, MF
    Zeni, L
    Rosenfeld, RD
    Stark, KL
    Haniu, M
    BIOCHEMISTRY, 1998, 37 (35) : 12172 - 12177
  • [10] Agouti-related protein SAR and homology molecular modeling of the melanocortin-4 receptor
    Haskell-Luevano, C
    Joseph, C
    Xiang, Z
    Scott, J
    Wilson, K
    Millard, W
    Edison, A
    Wilczynski, A
    BIOPOLYMERS, 2005, 80 (04) : 536 - 536
12345