Optimized hydrophobically modified chitosan cryogels for strength and drug delivery systems

被引：12
|
作者：
Evans, Courtney [1 ]
Morimitsu, Yuto [1 ]
Hisadome, Tsubasa [1 ]
Inomoto, Futo [1 ]
Yoshida, Masahiro [1 ]
Takei, Takayuki [1 ]
机构：
[1] Kagoshima Univ, Grad Sch Sci & Engn, Dept Chem Engn, 1-21-40 Korimoto, Kagoshima 8900065, Japan
来源：
JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2021年 / 132卷 / 01期
基金：
日本学术振兴会;
关键词：
Cryogel; Chitosan; Hydrophobic modification; Biomedical material; Drug carrier; IN-VITRO; HYDROGELS; CHITIN; BIOMATERIALS;
D O I：
10.1016/j.jbiosc.2021.03.008
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This research reports the success of the fabrication of hydrophobically modified chitosan cryogel. Chitosan was modified with alkyl groups through reductive animation. By varying the alkyl chain length and the substitution degree, the resulting cryogel could be optimized for strength, and the adsorption and release of hydrophobic dye, a model for hydrophobic medicines. By optimizing these attributes, the hydrogel was found to have the potential as a biomedical material. (C) 2021, The Society for Biotechnology, Japan. All rights reserved.
引用
收藏
页码：81 / 87
页数：7
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