Outcomes of furazolidone- and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication

被引:31
作者
Zhang, Ya-Wen [1 ,2 ]
Hu, Wei-Ling [1 ,2 ]
Cai, Yuan [1 ]
Zheng, Wen-Fang [1 ,2 ]
Du, Qin [3 ]
Kim, John J. [4 ]
Kao, John Y. [5 ]
Dai, Ning [1 ]
Si, Jian-Min [1 ,2 ]
机构
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gastroenterol, 3 East Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Gastroenterol, Hangzhou 310016, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Gastroenterol, Hangzhou 310009, Zhejiang, Peoples R China
[4] Loma Linda Univ, Div Gastroenterol, Loma Linda, CA 92354 USA
[5] Univ Michigan, Dept Internal Med, Div Gastroenterol, Michigan Med, Ann Arbor, MI 48109 USA
关键词
Helicobacter pylori; Furazolidone; Quadruple regimen; Side effects; Eradication; TRIPLE THERAPY; BISMUTH; RESISTANCE; REGIMENS; GASTROENTEROLOGY; CLARITHROMYCIN; METAANALYSIS; RABEPRAZOLE; 1ST-LINE; EFFICACY;
D O I
10.3748/wjg.v24.i40.4596
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM To evaluate the outcomes of furazolidone- and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori (H. pylori) infection and identify predictors of failed eradication. METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy (January 2015 to December 2015) who received the C-13-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication. RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval (CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0% (95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3% (95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144 (17%) reported treatment-related adverse events including 24 (3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio (AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments (AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy (AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy (AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone- and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication.
引用
收藏
页码:4596 / 4605
页数:10
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