Global analysis of differentially expressed genes in androgen-independent prostate cancer

被引：30
|
作者：
Wei, Q.
Li, M.
Fu, X.
Tang, R.
Na, Y.
Jiang, M.
Li, Y. [1 ]
机构：
[1] Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China
[2] Peking Univ, First Hosp, Dept Urol, Beijing 100871, Peoples R China
来源：
PROSTATE CANCER AND PROSTATIC DISEASES | 2007年 / 10卷 / 02期
基金：
中国国家自然科学基金;
关键词：
androgen independent; expression profile; hormone; angiogenesis; microarray;
D O I：
10.1038/sj.pcan.4500933
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Progression to androgen independent ( AI) is the main cause of death in prostate cancer, and the mechanism is still unclear. By reviewing the expression profiles of 26 prostate cancer samples in a holistic view, we found a group of genes differentially expressed in AI compared with androgen-dependent groups ( P- value < 0.01, t- test). Focusing on apoptosis, proliferation, hormone and angiogenesis, we found a group of genes such as thioredoxin domain containing 5, tumor necrosis factor receptor superfamily, member 10a, ribosomal protein S19 and Janus kinase 2 upregulated in AI prostate cancer, could play important roles in the transition from AD to AI and could be biomarkers of prognosis.
引用
收藏
页码：167 / 174
页数：8
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