Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

被引：37

作者：

Renoux, Celine ^{[1
,2
,7
]}

Romana, Marc ^{[3
,7
]}

Joly, Philippe ^{[1
,2
,7
]}

Ferdinand, Severine ^{[3
,7
]}

Faes, Camille ^{[2
,7
]}

Lemonne, Nathalie ^{[4
]}

Skinner, Sarah ^{[2
,7
]}

Garnier, Nathalie ^{[5
]}

Etienne-Julan, Maryse ^{[4
]}

Bertrand, Yves ^{[5
]}

Petras, Marie ^{[4
]}

Cannas, Giovanna ^{[6
]}

Divialle-Doumdo, Lydia ^{[4
]}

Nader, Elie ^{[2
,7
]}

Cuzzubbo, Daniela ^{[5
]}

Lamarre, Yann ^{[3
,7
]}

Gauthier, Alexandra ^{[5
]}

Waltz, Xavier ^{[3
,7
]}

Kebaili, Kamila ^{[5
]}

Martin, Cyril ^{[2
,7
]}

Hot, Arnaud ^{[6
]}

Hardy-Dessources, Marie-Dominique ^{[3
,7
]}

Pialoux, Vincent ^{[2
,7
]}

Connes, Philippe ^{[2
,3
,7
,8
]}

机构：

[1] Hosp Civils Lyon, Unite Pathol Mol Globule Rouge, Lab Biochim & Biol Mol, Hop Edouard Herriot, Lyon, France

[2] Univ Lyon 1, Lab Interuniv Biol Motricite, Equipe Vasc Biol & Red Blood Cell, Lyon, France

[3] Univ Antilles Guyane, Hop Pointe A Pitre, UMR Inserm U1134, Hop Ricou, Pointe A Pitre 97159, Guadeloupe, France

[4] Hop Ricou, Hop Pointe A Pitre, Unite Transversale Drepanocytose, Pointe A Pitre 97159, Guadeloupe, France

[5] Hosp Civils Lyon, Inst Hematol & Oncol Pediat, Lyon, France

[6] Hosp Civils Lyon, Hop Edouard Herriot, Serv Med Interne, Lyon, France

[7] PRES Sorbonne, Lab Excellence Globule Rouge LABEX GR Ex, Paris, France

[8] Inst Univ France, Paris, France

来源：

PLOS ONE | 2016年 / 11卷 / 06期

关键词：

OXIDATIVE STRESS; VISCOSITY; CHILDREN; HYDROXYUREA; FREQUENCY; CRISES; AGGREGATION; THALASSEMIA; ADHESION; BALANCE;

D O I：

10.1371/journal.pone.0158182

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objectives Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown. Materials and Methods Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients. Results Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age. Conclusion The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders.

引用

页数：11

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