The oriented development of antituberculotics (Part II):: Halogenated 3-(4-alkylphenyl)-1,3-benzoxazine-2,4-(3H)-diones

被引：13
作者：
Waisser, Karel
Matyk, Josef
Divisova, Hana
Husakova, Petra
Kunes, Jiri
Klimesova, Vera
Palat, Karel
Kaustova, Jarmila
机构：
[1] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Inorgan & Organ Chem, CZ-50005 Hradec Kralove, Czech Republic
[2] Reg Inst Publ Hlth, Dept Diagnost Mycobacteria, Ostrava, Czech Republic
来源：
ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 05期
关键词：
antimycobacterial activity; antituberculotic activity; benzoxazine; tuloerculostatics;
D O I：
10.1002/ardp.200600002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Based on our previous studies, 21 new halogenated 3-(4-allcylphenyl)-1,3-benzoxazine-2,4-(3H)-diones were synthesized by the reaction of salicylanilides and methyl-chloroformate. All compounds were screened in vitro against three different strains of mycobacterium, and Free-Wilson method was used to establish structure-activity relationships. 6-Bromo-3-(4-butylphenyl)-1,3-benzoxazine-2,4-(3H)-dione 3b proved to be the most active compound of the series.
引用
收藏
页码：264 / 267
页数：4
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