Probing inclusion complexes of cyclodextrins with amino acids by physicochemical approach

被引：59

作者：

Roy, Mahendra Nath ^{[1
]}

Roy, Aditi ^{[1
]}

Saha, Subhadeep ^{[1
]}

机构：

[1] Univ North Bengal, Dept Chem, Darjeeling 734013, India

来源：

CARBOHYDRATE POLYMERS | 2016年 / 151卷

关键词：

Inclusion complex; Cyclodextrin; Amino acid; Spectroscopic investigation; Physicochemical studies; Thermodynamic parameter; BETA-CYCLODEXTRIN; IONIC LIQUID; HOST; LEUCINE; ALPHA;

D O I：

10.1016/j.carbpol.2016.05.100

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Formations of host-guest inclusion complexes of two natural amino acids, viz., L-Leucine and L-Isoleucine as guests with Li and (3-cyclodextrins have been investigated which include diverse applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing etc. Surface tension and conductivity studies establish the formation of inclusion complexes with 1:1 stoichiometry. The interactions of cyclodextrins with amino acids have been supported by density, viscosity, refractive index, hydration and solvation number measurements indicating higher degree of inclusion in case of Li-cyclodextrin. L-Leucine interacts more with the hydrophobic cavity of cyclodextrin than its isomer. With the help of stability constant by NMR titration, hydrophobic effect, H-bonds and structural effects the formations of inclusion complexes have been explained. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：458 / 466

页数：9

共 36 条

[1] Electrical conductance studies in aqueous solutions with glutamic ions [J].