Benign familial chronic pemphigus (Hailey-Hailey disease)

被引：1

作者：

Pissoat, L. ^{[1
]}

Obrigkeit, D. Hoeller ^{[1
]}

机构：

[1] Univ Klinikum RWTH Aachen, Klin Allergol & Dermatol, D-52074 Aachen, Germany

来源：

HAUTARZT | 2010年 / 61卷 / 05期

关键词：

Hailey-Hailey disease; Pemphigus; Acantholysis; Ca2+-ATPase; Carbon dioxide laser; MUTATIONS; ATP2C1;

D O I：

10.1007/s00105-010-1954-3

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Benign familial chronic pemphigus (Hailey-Hailey disease) is an autosomal dominant blistering disease caused by mutations in the ATP2C1 gene encoding a calcium-ATPase which is crucial for intercellular epidermal adhesion. We present a 37-year-old woman with erosions and crusts in both axillary areas. Based on clinical and histological findings, she was diagnosed with benign familial chronic pemphigus. The lesions healed after ablative carbon dioxide laser therapy; no relapse occurred within a follow-up of two years.

引用

页码：376 / 378

页数：3

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