Deconstructing interstitial fibrosis and tubular atrophy: a step toward precision medicine in renal transplantation

被引：12

作者：

Mengel, Michael ^{[1
]}

机构：

[1] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2S2, Canada

来源：

KIDNEY INTERNATIONAL | 2017年 / 92卷 / 03期

关键词：

DONOR-SPECIFIC ANTIBODY; CREATININE; BIOPSIES;

D O I：

10.1016/j.kint.2017.04.041

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The prerequisite for successful treatment is an accurate diagnosis, a concept coined precision medicine. Progression of interstitial fibrosis and tubular atrophy is widely considered the natural course for all transplanted kidneys. In this issue, Gosset et al. describe discrete disease entities in individual patients and their contribution to interstitial fibrosis and tubular atrophy and its progression. This represents a major step forward in stratifying patients for targeted treatment trials (i.e., a step toward precision medicine in renal transplantation).

引用

页码：553 / 555

页数：4

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