Mitochondrial dysfunction in AIDS and its treatment

被引:58
作者
Gerschenson, M
Brinkman, K
机构
[1] Univ Hawaii Manoa, Leahi Hosp, Hawaii Aids Clin Res Program, John A Burns Sch Med, Honolulu, HI 96816 USA
[2] Onze Lieve Vrouw Hosp, Dept Internal Med, NL-1091 AC Amsterdam, Netherlands
基金
美国国家卫生研究院;
关键词
antiretroviral; apoptosis; DNA polymerase-gamma; HIV; mitochondria; uncoupling protein;
D O I
10.1016/j.mito.2004.07.025
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Advances in anti-retroviral therapy (ART) has led to improved survival of patients infected with the human immunodeficiency virus (HIV). ART for HIV patients is composed of a combination of nucleoside reverse transcriptase inhibitors (NRTI) and/or a non-nucleoside reverse transcriptase inhibitor (NNRTI), and/or a protease inhibitor (PI). The long-term exposure to ART and HIV are causing mitochondrial toxicities, such as myopathies, neuropathy, myelopoiesis, pancreatitis, lactic acidosis, hepatic steatosis, and lipodystrophy. The mitochondrial pathogenesis has been believed to be due exclusively to NRTI-induced inhibition of DNA polymerase-gamma; it is now apparent that the etiology is far more complex, involving multiple mechanisms as well as an effect by HIV per se. Current therapy for patients includes interruption or change in medications and mitochondrial co-factors. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码:763 / 777
页数:15
相关论文
共 158 条
[1]   Lactic acidemia in human immunodeficiency virus-uninfected infants exposed to perinatal antiretroviral therapy [J].
Alimenti, A ;
Burdge, DR ;
Ogilvie, GS ;
Money, DM ;
Forbes, JC .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2003, 22 (09) :782-788
[2]   PGC-l-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells [J].
Andersson, U ;
Scarpulla, RC .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3738-3749
[3]   Lactic acidosis in HIV infected patients: a systematic review of published cases [J].
Arenas-Pinto, A ;
Grant, AD ;
Edwards, S ;
Weller, IVD .
SEXUALLY TRANSMITTED INFECTIONS, 2003, 79 (04) :340-344
[4]   Severe lactic acidosis and thiamine administration in an HIV-infected patient on HAART [J].
Arici, C ;
Tebaldi, A ;
Quinzan, GP ;
Maggiolo, F ;
Ripamonti, D ;
Suter, F .
INTERNATIONAL JOURNAL OF STD & AIDS, 2001, 12 (06) :407-409
[5]   Mitochondria in HIV-1-induced apoptosis [J].
Arnoult, D ;
Petit, F ;
Lelièvre, JD ;
Estaquier, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (03) :561-574
[6]  
AYERS KM, 1988, AM J MED, V85, P186
[7]   Mitochondrion-mediated apoptosis in HIV-1 infection [J].
Badley, AD ;
Roumier, T ;
Lum, JJ ;
Kroemer, G .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (06) :298-305
[8]  
BARAM D, 1993, ANN INTERN MED, V119, P345, DOI 10.7326/0003-4819-119-4-199308150-00024
[9]   3'-Azido-3'-deoxythymidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator [J].
Barile, M ;
Valenti, D ;
Passarella, S ;
Quagliariello, E .
BIOCHEMICAL PHARMACOLOGY, 1997, 53 (07) :913-920
[10]   Persistent mitochondrial dysfunction in HIV-1-exposed but uninfected infants: clinical screening in a large prospective cohort [J].
Barret, B ;
Tardieu, M ;
Rustin, P ;
Lacroix, C ;
Chabrol, B ;
Desguerre, I ;
Dollfus, C ;
Mayaux, MJ ;
Blanche, S .
AIDS, 2003, 17 (12) :1769-1785