Interleukin-10 gene polymorphism rs1800896 is associated with post-bronchiolitis asthma at 11-13 years of age
被引:10
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Holster, Annukka
[1
,2
,3
]
Nuolivirta, Kirsi
论文数: 0引用数: 0
h-index: 0
机构:
Seinajoki Cent Hosp, Dept Paediat, Seinajoki, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Nuolivirta, Kirsi
[3
]
Tormanen, Sari
论文数: 0引用数: 0
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机构:
Tampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Tampere Univ Hosp, Arvo2 Bldg, Tampere 33014, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Tormanen, Sari
[1
,2
]
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Lauhkonen, Eero
[1
,2
]
Terasjarvi, Johanna
论文数: 0引用数: 0
h-index: 0
机构:
Turku Univ, Inst Biomed, Turku, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Terasjarvi, Johanna
[4
]
Vuononvirta, Juho
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Turku Univ, Inst Biomed, Turku, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Vuononvirta, Juho
[4
]
Koponen, Petri
论文数: 0引用数: 0
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Tampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Tampere Univ Hosp, Arvo2 Bldg, Tampere 33014, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Koponen, Petri
[1
,2
]
Helminen, Merja
论文数: 0引用数: 0
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Tampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Tampere Univ Hosp, Arvo2 Bldg, Tampere 33014, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Helminen, Merja
[1
,2
]
He, Qiushui
论文数: 0引用数: 0
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机构:
Turku Univ, Inst Biomed, Turku, Finland
Capital Med Univ, Dept Med Microbiol, Beijing, Peoples R ChinaTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
He, Qiushui
[4
,5
]
Korppi, Matti
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Tampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Tampere Univ Hosp, Arvo2 Bldg, Tampere 33014, FinlandTampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
Korppi, Matti
[1
,2
]
机构:
[1] Tampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
[2] Tampere Univ Hosp, Arvo2 Bldg, Tampere 33014, Finland
[3] Seinajoki Cent Hosp, Dept Paediat, Seinajoki, Finland
[4] Turku Univ, Inst Biomed, Turku, Finland
[5] Capital Med Univ, Dept Med Microbiol, Beijing, Peoples R China
Aim Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is involved with bronchiolitis and asthma. We evaluated associations between four IL-10 polymorphisms, namely rs1800871, rs1800872, rs1800890 and rs1800896, and post-bronchiolitis asthma in young adolescents. Methods The cohort consisted of 125 children hospitalised for bronchiolitis at Tampere University Hospital, Finland, in 2000-2004, at less than six months of age. At 11-13 years, asthma diagnoses and asthma-presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Data on the four polymorphisms and their genotypes, haplotypes and allele frequencies were analysed in relation to asthma, allergic rhinitis and asthma medication. Results The variant IL-10 rs1800896 genotype was associated with less persistent asthma at five to seven and 11-13 years of age (4.3 versus 15.2%, p = 0.04) than the wild genotype and less ICS use during the previous 12 months (5.4 versus 18.2%, p = 0.03), as was the variant allele G. Allele A was associated with more persistent asthma and ICS use. The significant differences between the variant and wild genotypes were lost in adjusted logistic regression, but the direction of the association remained. Conclusion IL-10 rs1800896 gene polymorphism was associated with post-bronchiolitis asthma at 11-13 years of age in children hospitalised for bronchiolitis at less than six months of age.
机构:
Tampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Tampere Univ, Paediat Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Helminen, Merja
;
Nuolivirta, Kirsi
论文数: 0引用数: 0
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Tampere Univ, Tampere & Seinajoki Cent Hosp, Paediat Res Ctr, Seinajoki, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Nuolivirta, Kirsi
;
Virta, Miia
论文数: 0引用数: 0
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机构:
Univ Tampere, Sch Med, Tampere Univ Hosp, Dept Microbiol & Immunol,Lab Ctr, FIN-33101 Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Virta, Miia
;
Halkosalo, Anne
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机构:
Univ Tampere, Sch Med, Vaccine Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Halkosalo, Anne
;
Korppi, Matti
论文数: 0引用数: 0
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机构:
Tampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Tampere Univ, Paediat Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Korppi, Matti
;
Vesikari, Timo
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Univ Tampere, Sch Med, Vaccine Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Vesikari, Timo
;
Hurme, Mikko
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Univ Tampere, Sch Med, Tampere Univ Hosp, Dept Microbiol & Immunol,Lab Ctr, FIN-33101 Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Hussein, Y. M.
;
Alzahrani, S. S.
论文数: 0引用数: 0
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Taif Univ, Fac Med, Dept Community Med, At Taif, Saudi ArabiaTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Alzahrani, S. S.
;
Alharthi, A. A.
论文数: 0引用数: 0
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机构:
Taif Univ, Fac Med, Dept Pediat, At Taif, Saudi ArabiaTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Alharthi, A. A.
;
Ghonaim, M. M.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Menoufia Univ, Fac Med, Dept Med Microbiol & Immunol, Menoufia, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Ghonaim, M. M.
;
Alhazmi, A. S.
论文数: 0引用数: 0
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Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi ArabiaTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Alhazmi, A. S.
;
Eed, E. M.
论文数: 0引用数: 0
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机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Menoufia Univ, Fac Med, Dept Med Microbiol & Immunol, Menoufia, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Eed, E. M.
;
Shalaby, S. M.
论文数: 0引用数: 0
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Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
机构:
Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Hyun, Myung-Han
;
Lee, Chung-Ho
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Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Lee, Chung-Ho
;
Kang, Min-Hyung
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Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Kang, Min-Hyung
;
Park, Bong-Kyung
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Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Park, Bong-Kyung
;
Lee, Young Ho
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Seoul 136705, South Korea
Korea Univ, Coll Med, Dept Internal Med, Anam Hosp,Div Rheumatol, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
机构:
Tampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Tampere Univ, Paediat Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Helminen, Merja
;
Nuolivirta, Kirsi
论文数: 0引用数: 0
h-index: 0
机构:
Tampere Univ, Tampere & Seinajoki Cent Hosp, Paediat Res Ctr, Seinajoki, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Nuolivirta, Kirsi
;
Virta, Miia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tampere, Sch Med, Tampere Univ Hosp, Dept Microbiol & Immunol,Lab Ctr, FIN-33101 Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Virta, Miia
;
Halkosalo, Anne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tampere, Sch Med, Vaccine Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Halkosalo, Anne
;
Korppi, Matti
论文数: 0引用数: 0
h-index: 0
机构:
Tampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Tampere Univ, Paediat Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Korppi, Matti
;
Vesikari, Timo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tampere, Sch Med, Vaccine Res Ctr, Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
Vesikari, Timo
;
Hurme, Mikko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tampere, Sch Med, Tampere Univ Hosp, Dept Microbiol & Immunol,Lab Ctr, FIN-33101 Tampere, FinlandTampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland
机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Hussein, Y. M.
;
Alzahrani, S. S.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Fac Med, Dept Community Med, At Taif, Saudi ArabiaTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Alzahrani, S. S.
;
Alharthi, A. A.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Fac Med, Dept Pediat, At Taif, Saudi ArabiaTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Alharthi, A. A.
;
Ghonaim, M. M.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Menoufia Univ, Fac Med, Dept Med Microbiol & Immunol, Menoufia, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Ghonaim, M. M.
;
Alhazmi, A. S.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi ArabiaTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Alhazmi, A. S.
;
Eed, E. M.
论文数: 0引用数: 0
h-index: 0
机构:
Taif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Menoufia Univ, Fac Med, Dept Med Microbiol & Immunol, Menoufia, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
Eed, E. M.
;
Shalaby, S. M.
论文数: 0引用数: 0
h-index: 0
机构:
Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, EgyptTaif Univ, Fac Appl Med Sci, Med Labs Dept, Al Huwaya, Saudi Arabia
机构:
Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Hyun, Myung-Han
;
Lee, Chung-Ho
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Lee, Chung-Ho
;
Kang, Min-Hyung
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Kang, Min-Hyung
;
Park, Bong-Kyung
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea
Park, Bong-Kyung
;
Lee, Young Ho
论文数: 0引用数: 0
h-index: 0
机构:
Korea Univ, Coll Med, Seoul 136705, South Korea
Korea Univ, Coll Med, Dept Internal Med, Anam Hosp,Div Rheumatol, Seoul 136705, South KoreaKorea Univ, Coll Med, Seoul 136705, South Korea