Interleukin-10 gene polymorphism rs1800896 is associated with post-bronchiolitis asthma at 11-13 years of age

被引:10
作者
Holster, Annukka [1 ,2 ,3 ]
Nuolivirta, Kirsi [3 ]
Tormanen, Sari [1 ,2 ]
Lauhkonen, Eero [1 ,2 ]
Terasjarvi, Johanna [4 ]
Vuononvirta, Juho [4 ]
Koponen, Petri [1 ,2 ]
Helminen, Merja [1 ,2 ]
He, Qiushui [4 ,5 ]
Korppi, Matti [1 ,2 ]
机构
[1] Tampere Univ, Ctr Child Hlth Res, Arvo2 Bldg, Tampere 33014, Finland
[2] Tampere Univ Hosp, Arvo2 Bldg, Tampere 33014, Finland
[3] Seinajoki Cent Hosp, Dept Paediat, Seinajoki, Finland
[4] Turku Univ, Inst Biomed, Turku, Finland
[5] Capital Med Univ, Dept Med Microbiol, Beijing, Peoples R China
关键词
Asthma; Bronchiolitis; Genotypes; Interleukin; 10; Polymorphisms; IL10; POLYMORPHISMS; ATOPIC ASTHMA; SUSCEPTIBILITY; IMMUNITY; CHILDREN; INNATE; WHEEZE; ROLES; RISK;
D O I
10.1111/apa.14838
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aim Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is involved with bronchiolitis and asthma. We evaluated associations between four IL-10 polymorphisms, namely rs1800871, rs1800872, rs1800890 and rs1800896, and post-bronchiolitis asthma in young adolescents. Methods The cohort consisted of 125 children hospitalised for bronchiolitis at Tampere University Hospital, Finland, in 2000-2004, at less than six months of age. At 11-13 years, asthma diagnoses and asthma-presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Data on the four polymorphisms and their genotypes, haplotypes and allele frequencies were analysed in relation to asthma, allergic rhinitis and asthma medication. Results The variant IL-10 rs1800896 genotype was associated with less persistent asthma at five to seven and 11-13 years of age (4.3 versus 15.2%, p = 0.04) than the wild genotype and less ICS use during the previous 12 months (5.4 versus 18.2%, p = 0.03), as was the variant allele G. Allele A was associated with more persistent asthma and ICS use. The significant differences between the variant and wild genotypes were lost in adjusted logistic regression, but the direction of the association remained. Conclusion IL-10 rs1800896 gene polymorphism was associated with post-bronchiolitis asthma at 11-13 years of age in children hospitalised for bronchiolitis at less than six months of age.
引用
收藏
页码:2064 / 2069
页数:6
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