ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

被引:13
作者
Poznyak, Anastasia V. [1 ]
Bezsonov, Evgeny E. [2 ,3 ]
Eid, Ali H. [4 ,5 ]
Popkova, Tatyana V. [6 ]
Nedosugova, Ludmila V. [7 ]
Starodubova, Antonina V. [8 ,9 ]
Orekhov, Alexander N. [1 ,2 ,3 ]
机构
[1] Skolkovo Innovat Ctr, Atherosclerosis Res Inst, Moscow 121609, Russia
[2] Inst Human Morphol, Lab Cellular & Mol Pathol Cardiovasc Syst, 3 Tsyurupa St, Moscow 117418, Russia
[3] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, 8 Baltiiskaya St, Moscow 125315, Russia
[4] Qatar Univ, QU Hlth, Coll Med, Dept Basic Med Sci, POB 2713, Doha 2713, Qatar
[5] Qatar Univ, QU Hlth, Biomed & Pharmaceut Res Unit, POB 2713, Doha 2713, Qatar
[6] VA Nasonova Inst Rheumatol, 34A Kashirskoye Shosse, Moscow 115522, Russia
[7] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Fed State Autonomous Educ Inst Higher Educ, Minist Hlth Russian Federat, 8-2 Trubenskaya St, Moscow 119991, Russia
[8] Fed Res Ctr Nutr Biotechnol & Food Safety, 2-14 Ustinsky Passage, Moscow 109240, Russia
[9] Pirogov Russian Natl Res Med Univ, 1 Ostrovitianov St, Moscow 117997, Russia
基金
俄罗斯科学基金会;
关键词
COVID-19; coronavirus disease; atherosclerosis; ACE2; ANGIOTENSIN-II;
D O I
10.3390/ijms22094691
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis.
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页数:11
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