Increased Prevalence of Atopic Dermatitis in Children Aged 0-3 Years Highly Exposed to Parabens

被引:8
|
作者
Arafune, Johichi [1 ]
Tsujiguchi, Hiromasa [1 ,2 ]
Hara, Akinori [1 ,2 ]
Shimizu, Yukari [3 ]
Hori, Daisuke [4 ]
Thao Thi Thu Nguyen [5 ]
Suzuki, Fumihiko [1 ]
Hamagishi, Toshio [1 ]
Yamada, Yohei [1 ]
Nakamura, Haruki [1 ]
Yoshikawa, Takahiro [1 ]
Hayashi, Koichiro [1 ]
Shibata, Aki [1 ]
Fukutomi, Yuma [6 ]
Ohya, Yukihiro [7 ]
Yamamoto-Hanada, Kiwako [7 ]
Muto, Go [8 ,9 ]
Hirota, Ryoji [10 ]
Konoshita, Tadashi [11 ]
Kambayashi, Yasuhiro [1 ,12 ]
Nakamura, Hiroyuki [1 ,2 ]
机构
[1] Kanazawa Univ, Dept Environm & Prevent Med, Grad Sch Med Sci, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan
[2] Kanazawa Univ, Adv Prevent Med Ctr, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan
[3] Komatsu Univ, Fac Hlth Sci, Dept Nursing, 14-1 Mukaimotorimachi, Mukaimotorimachi, Ishikawa 9230961, Japan
[4] Univ Tsukuba, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan
[5] Haiphong Univ Med & Pharm, Fac Publ Hlth, Hai Phong 180000, Ngo Quyen, Vietnam
[6] Natl Hosp Org, Clin Res Ctr Allergy & Rheumatol, Sagamihara Natl Hosp, Minami Ku, 18-1 Sakuradai, Sagamihara, Kanagawa 2520392, Japan
[7] Natl Ctr Child Hlth & Dev, Allergy Ctr, Setagaya Ku, 2-10-1 Okura, Tokyo 1578535, Japan
[8] Kitasato Univ, Dept Hyg, Sch Med, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520374, Japan
[9] Chiba Univ, Ctr Prevent Med Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan
[10] Matsumoto Univ, Grad Sch Hlth Sci, 2095-1 Niimura, Matsumoto 3901295, Japan
[11] Univ Fukui, Dept Internal Med 3, Fac Med Sci, 23-3 Mat Suoka Shimoaizaki, Fukui 9101193, Japan
[12] Okayama Univ Sci, Fac Vet Med, Dept Publ Hlth, 1-3 Ikoinooka, Imabari, Ehime 7948555, Japan
关键词
allergy; atopic dermatitis; children; epidemiology; paraben; URINARY LEVELS; TRICLOSAN; ASSOCIATIONS; SENSITIZATION;
D O I
10.3390/ijerph182111657
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0-3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations (p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup's index, and passive smoking (p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary.
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页数:10
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