Integrative Frequency Power of EEG Correlates with Progression of Mild Cognitive Impairment to Dementia in Parkinson's Disease

被引:17
|
作者
Gu, Youquan [1 ,2 ]
Chen, Jun [2 ]
Lu, Yaqin [2 ]
Pan, Suyue [1 ]
机构
[1] Southern Med Univ, Nanfang Hosp, Dept Neurol, 1838 Guangzhoudadaobei Rd, Guangzhou 510515, Guangdong, Peoples R China
[2] Lanzhou Univ, Hosp 1, Dept Neurol, Lanzhou 730000, Peoples R China
关键词
Parkinson's disease; mild cognitive impairment; dementia; electroencephalography; progression; ALZHEIMERS-DISEASE; ELECTROENCEPHALOGRAPHY; CLINICIAN;
D O I
10.1177/1550059414543796
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Clinically, predicting the progression of mild cognitive impairment (MCI) and diagnosing dementia in Parkinson's disease (PD) are difficult. This study aims to explore an integrative electroencephalography (EEG) frequency power that could be used to predict the progression of MCI in PD patients. Twenty-six PD patients, in this study, were divided into the mild cognitive impairment group (PDMCI, 17 patients) and dementia group (PDD, 9 patients) according to cognitive performance. Beta peak frequency, alpha relative power, and alpha/theta power were recorded and analyzed for the prediction. Mini Mental State Examination (MMSE) scores at initiation, in the first year, and in the second year were examined. The sensitivity, specificity, positive predictive value, Matthew correlation coefficient, and positive likelihood ratio were calculated in both the integrative EEG biomarkers and single best biomarker. Of the 17 patients with MCI for 2 years, 6 progressed to dementia. Integrative EEG biomarkers, mainly associated with beta peak frequency, can predict conversion from MCI to dementia. These biomarkers had sensitivity of 82% and specificity of 78%, compared with sensitivity of 61% and specificity of 58% of the beta peak frequency. In conclusion, the integrative EEG frequency powers were more sensitive and specific to MCI progression in PD patients.
引用
收藏
页码:113 / 117
页数:5
相关论文
共 50 条
  • [1] Subtypes of mild cognitive impairment in Parkinson's disease: Progression to dementia
    Janvin, Carmen Cristea
    Larsen, Jan Petter
    Aarsland, Dag
    Hugdahl, Kenneth
    MOVEMENT DISORDERS, 2006, 21 (09) : 1343 - 1349
  • [2] Mild cognitive impairment in Parkinson's disease: Diagnosis and progression to dementia
    Galtier, Ivan
    Nieto, Antonieta
    Lorenzo, Jesus N.
    Barroso, Jose
    JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2016, 38 (01) : 40 - 50
  • [3] Dementia, Mild Cognitive Impairment and Quantitative EEG in Patients With Parkinson's Disease
    Fonseca, L. C.
    Tedrus, G. M. A. S.
    Letro, G. H.
    Bossoni, A. S.
    CLINICAL EEG AND NEUROSCIENCE, 2009, 40 (03) : 168 - 172
  • [4] Anosognosia for cognitive and behavioral symptoms in Parkinson's disease with mild dementia and mild cognitive impairment: Frequency and neuropsychological/neuropsychiatric correlates
    Orfei, Maria Donata
    Assogna, Francesca
    Pellicano, Clelia
    Pontieri, Francesco Ernesto
    Caltagirone, Carlo
    Pierantozzi, Mariangela
    Stefani, Alessandro
    Spalletta, Gianfranco
    PARKINSONISM & RELATED DISORDERS, 2018, 54 : 62 - 67
  • [5] Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease
    Cholerton, Brenna
    Johnson, Catherine O.
    Fish, Brian
    Quinn, Joseph F.
    Chung, Kathryn A.
    Peterson-Hiller, Amie L.
    Rosenthal, Liana S.
    Dawson, Ted M.
    Albert, Marilyn S.
    Hu, Shu-Ching
    Mata, Ignacio F.
    Leverenz, James B.
    Poston, Kathleen L.
    Montine, Thomas J.
    Zabetian, Cyrus P.
    Edwards, Karen L.
    PARKINSONISM & RELATED DISORDERS, 2018, 50 : 29 - 36
  • [6] DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE
    Caixeta, Leonardo
    Soares, Vania Lucia
    Soares, Candida Dias
    Reis, Giane
    ARQUIVOS DE NEURO-PSIQUIATRIA, 2009, 67 (3B) : 959 - 959
  • [7] Mild cognitive impairment and dementia in Parkinson's disease
    Petrovic, M.
    Stefanova, E.
    Knezevic, Z.
    Idrizovic, Z.
    Kostic, V.
    EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 : 519 - 519
  • [8] Mild cognitive impairment and dementia in Parkinson's disease
    Wolters, E. C.
    Stam, C. J.
    Bosboom, J. L.
    Stoffers, D.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2006, 248 (1-2) : 313 - 313
  • [9] DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE
    Almeida Souza Tedrus, Gloria Maria
    Fonseca, Lineu Correa
    Letro, Grace Helena
    Bossoni, Alexandre Souza
    Samara, Adriana Bastos
    ARQUIVOS DE NEURO-PSIQUIATRIA, 2009, 67 (04) : 1164 - 1164
  • [10] Incidence of Mild Cognitive Impairment and Dementia in Parkinson's Disease: The Parkinson's Disease Cognitive Impairment Study
    Nicoletti, Alessandra
    Luca, Antonina
    Baschi, Roberta
    Cicero, Calogero Edoardo
    Mostile, Giovanni
    Davi, Marco
    Pilati, Laura
    Restivo, Vincenzo
    Zappia, Mario
    Monastero, Roberto
    FRONTIERS IN AGING NEUROSCIENCE, 2019, 11