Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches

被引：15

作者：

Liu, Wenjing ^{[1
,2
]}

Guo, Yourong ^{[3
]}

Wang, Kaizhe ^{[1
,2
]}

Zhou, Xingfei ^{[4
]}

Wang, Ying ^{[1
,5
]}

Lu, Junhong ^{[1
,5
]}

Shao, Zhifeng ^{[3
]}

Hu, Jun ^{[1
,5
,6
]}

Czajkowsky, Daniel M. ^{[3
]}

Li, Bin ^{[1
,5
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Biomed Engn, BioID Ctr, Shanghai 200240, Peoples R China

[4] Ningbo Univ, Sch Sci, Ningbo 315211, Zhejiang, Peoples R China

[5] Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai 201210, Peoples R China

[6] Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201204, Peoples R China

来源：

NANOSCALE | 2019年 / 11卷 / 37期

基金：

中国国家自然科学基金;

关键词：

RESOLUTION; RECOGNITION; MECHANICS; PROTEINS;

D O I：

10.1039/c9nr05234h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Atomic force microscopy-based single-molecule-force spectroscopy is limited by low throughput. We introduce addressable DNA origami to study multiple target molecules. Six target DNAs that differed by only a single base-pair mismatch were clearly differentiated a rupture force of only 4 pN.

引用

页码：17206 / 17210

页数：5

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