GABA and Homovanillic Acid in the Plasma of Schizophrenic and Bipolar I Patients

被引：30

作者：

Arrue, Aurora ^{[1
]}

Davila, Ricardo ^{[1
]}

Zumarraga, Mercedes ^{[1
]}

Basterreche, Nieves ^{[2
]}

Gonzalez-Torres, Miguel A. ^{[3
]}

Goienetxea, Biotza ^{[2
]}

Zamalloa, Maria I. ^{[1
]}

Anguiano, Juan B. ^{[4
]}

Guimon, Jose ^{[5
]}

机构：

[1] Hosp Zamudio, Dept Invest Neuroquim, Zamudio 48170, Vizcaya, Spain

[2] Hosp Zamudio, Unidad Hospitalizac Agudos, Vizcaya, Spain

[3] Hosp Basurto, Dept Psiquiatria, Bilbao, Spain

[4] Ctr Salud Mental Ortuella, Serv Vasco Salud, Vizcaya, Spain

[5] Univ Basque Country, Dept Psiquiatria, Vizcaya, Spain

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 02期

关键词：

Plasma; Homovanillic acid; Gamma-aminobutyric acid; Schizophrenia; Bipolar disorder; GAMMA-AMINOBUTYRIC-ACID; POST-MORTEM BRAINS; CATECHOLAMINE METABOLITES; HALOPERIDOL RESPONSE; SODIUM VALPROATE; DOPAMINE; NEURONS; HVA; RISPERIDONE; EXPRESSION;

D O I：

10.1007/s11064-009-0048-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have determined the plasma (p) concentration of gamma-aminobutyric acid (GABA) and the dopamine metabolite homovanillic acid (HVA), and the pHVA/pGABA ratio in schizophrenic and bipolar patients. The research was undertaken in a geographic area with an ethnically homogeneous population. The HVA plasma concentrations were significantly elevated in the schizophrenic patients compared to the bipolar patients. The levels of pGABA was significantly lower in the two groups of patients compared to the control group, while the pHVA/pGABA ratio was significantly greater in the both groups of patients compared to the controls. As the levels of pHVA and pGABA are partially under genetic control it is better to compare their concentrations within an homogeneous population. The values of the ratio pHVA/pGABA are compatible with the idea of an abnormal dopamine-GABA interaction in schizophrenic and bipolar patients. The pHVA/pGABA ratio may be a good peripheral marker in psychiatric research.

引用

页码：247 / 253

页数：7

共 53 条

[1] Levels of gamma-aminobutyric acid in cerebrospinal fluid and plasma during alcohol withdrawal [J].

Adinoff, B ;

Kramer, GL ;

Petty, F .

PSYCHIATRY RESEARCH, 1995, 59 (1-2) :137-144

[2] Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects [J].

Akil, M ;

Pierri, JN ;

Whitehead, RE ;

Edgar, CL ;

Mohila, C ;

Sampson, AR ;

Lewis, DA .

AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (10) :1580-1589

[3]

*AM PSYCH ASS WASH, 2000, DIAGN STAT MAN MENT

[4] Biological Correlates of the Congruence and Incongruence of Psychotic Symptoms in Patients with Type 1 Bipolar Disorder [J].

Basterreche, Nieves ;

Davila, Ricardo ;

Zumarraga, Mercedes ;

Arrue, Aurora ;

Gonalez-Torres, Miguel Angel ;

Zamalloa, Maria I. ;

Anguiano, Juan B. ;

Guimon, Jose .

NEUROPSYCHOBIOLOGY, 2008, 58 (3-4) :111-117

[5] Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients [J].

Behar, KL ;

Rothman, DL ;

Petersen, KF ;

Hooten, M ;

Delaney, R ;

Petroff, OAC ;

Shulman, GI ;

Navarro, V ;

Petrakis, IL ;

Charney, DS ;

Krystal, JH .

AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (06) :952-954

[6]

Benes FM, 1996, SYNAPSE, V23, P237, DOI 10.1002/(SICI)1098-2396(199608)23:4<237::AID-SYN1>3.0.CO

[7]

2-8

[8]

BERRETTINI WH, 1983, BIOL PSYCHIAT, V18, P185

[9] PLASMA-CATECHOLAMINE METABOLITES AND TREATMENT RESPONSE AT NEUROLEPTIC STEADY-STATE [J].

BOWERS, MB ;

SWIGAR, ME ;

JATLOW, PI ;

HOFFMAN, FJ .

BIOLOGICAL PSYCHIATRY, 1989, 25 (06) :734-738

[10] GABAergic dysfunction in mood disorders [J].

Brambilla, P ;

Perez, J ;

Barale, F ;

Schettini, G ;

Soares, JC .

MOLECULAR PSYCHIATRY, 2003, 8 (08) :721-737

← 1 2 3 4 5 6 →