Cytokines and autoimmunity

被引：511
作者：
O'Shea, JJ
Ma, A
Lipsky, P
机构：
[1] NIAMSD, Lymphocyte Cell Biol Sect, Arthritis & Rheumat Branch, NIH, Bethesda, MD 20892 USA
[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA
[3] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 01期
关键词：
D O I：
10.1038/nri702
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, such as interleukin-2, tumour-necrosis factor and interferons - ostensibly, the 'bad guys' in terms of disease pathogenesis - are well known for the promotion of immune and inflammatory responses. However, these cytokines also have crucial immunosuppressive functions and so, paradoxically, can also be 'good guys'. The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review.
引用
收藏
页码：37 / 45
页数：9
相关论文
共 49 条
[41]   Regulatory T cells: Key controllers of immunologic self-tolerance [J].
Sakaguchi, S .
CELL, 2000, 101 (05) :455-458
[42]   Suppressor T cells: Rebirth, function and homeostasis [J].
Shevach, EM .
CURRENT BIOLOGY, 2000, 10 (15) :R572-R575
[43]   Antigen-independent Th2 cell differentiation by stimulation of CD28: Regulation via IL-4 gene expression and mitogen-activated protein kinase activation [J].
Skapenko, A ;
Lipsky, PE ;
Kraetsch, HG ;
Kalden, JR ;
Schulze-Koops, H .
JOURNAL OF IMMUNOLOGY, 2001, 166 (07) :4283-4292
[44]   Relation between occurrence of type 1 diabetes and asthma [J].
Stene, LC ;
Nafstad, P .
LANCET, 2001, 357 (9256) :607-608
[45]   Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo [J].
Suzuki, H ;
Zhou, YW ;
Kato, M ;
Mak, TW ;
Nakashima, I .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (11) :1561-1571
[46]   Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models [J].
Todd, JA ;
Wicker, LS .
IMMUNITY, 2001, 15 (03) :387-395
[47]   RETRACTED: Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death (Retracted article. See vol. 30, pg. 611, 2009) [J].
Van Parijs, L ;
Refaeli, Y ;
Lord, JD ;
Nelson, BH ;
Abbas, AK ;
Baltimore, D .
IMMUNITY, 1999, 11 (03) :281-288
[48]  
Wolf M, 2001, EUR J IMMUNOL, V31, P1637, DOI 10.1002/1521-4141(200106)31:6<1637::AID-IMMU1637>3.0.CO
[49]  
2-T
12345