Cytokines and autoimmunity

被引：505
作者：
O'Shea, JJ
Ma, A
Lipsky, P
机构：
[1] NIAMSD, Lymphocyte Cell Biol Sect, Arthritis & Rheumat Branch, NIH, Bethesda, MD 20892 USA
[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA
[3] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 01期
关键词：
D O I：
10.1038/nri702
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or action is thought to have a central role in the development of autoimmunity and autoimmune disease. Some cytokines, such as interleukin-2, tumour-necrosis factor and interferons - ostensibly, the 'bad guys' in terms of disease pathogenesis - are well known for the promotion of immune and inflammatory responses. However, these cytokines also have crucial immunosuppressive functions and so, paradoxically, can also be 'good guys'. The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review.
引用
收藏
页码：37 / 45
页数：9
相关论文
共 49 条
[1]   Roles of STAT3 defined by tissue-specific gene targeting [J].
Akira, S .
ONCOGENE, 2000, 19 (21) :2607-2611
[2]   Interferons α and β as immune regulators -: A new look [J].
Biron, CA .
IMMUNITY, 2001, 14 (06) :661-664
[3]   Autoimmune lymphoproliferative syndrome - A human disorder of abnormal lymphocyte survival [J].
Bleesing, JJH ;
Straus, SE ;
Fleisher, TA .
PEDIATRIC CLINICS OF NORTH AMERICA, 2000, 47 (06) :1291-+
[4]   Severe inflammatory arthritis and lymphadenopathy in the absence of TNF [J].
Campbell, IK ;
O'Donnell, K ;
Lawlor, KE ;
Wicks, IP .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (12) :1519-1527
[5]   A dual role for TNF-α in type 1 diabetes:: Islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis [J].
Christen, U ;
Wolfe, T ;
Möhrle, U ;
Hughes, AC ;
Rodrigo, E ;
Green, EA ;
Flavell, RA ;
von Herrath, MG .
JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7023-7032
[6]   Regulation of autoimmunity by proinflammatory cytokines [J].
Cope, AP .
CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (06) :669-676
[7]   Interleukin-2 and systemic lupus erythematosus - fifteen years later [J].
Crispin, JC ;
Alcocer-Varela, J .
LUPUS, 1998, 7 (04) :214-222
[8]   Advances in immunology - Autoimmune diseases [J].
Davidson, A ;
Diamond, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (05) :340-350
[9]   Cytokines that regulate autoimmune responses [J].
Falcone, M ;
Sarvetnick, N .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (06) :670-676
[10]  
FRUCHT DM, IN PRESS GENES IMMUN
12345